Diabetes is a global epidemic and it is increasing at an alarming rate. The International Diabetes Federation (IDF) projected that the total number of people with diabetes globally may increase by 48%, from 425 million (year 2017) to 629 million (year 2045). Moreover, diabetes had caused millions of deaths and the number is increasing drastically. Therefore, this paper addresses the background of diabetes and its complications. In addition, this paper investigates innovative applications and past researches in the areas of diabetes management system with applied eye fundus and tongue digital images. Different types of existing applied eye fundus and tongue digital image processing with diabetes management systems in the market and state-of-the-art machine learning techniques from previous literature have been reviewed. The implication of this paper is to have an overview in diabetic research and what new machine learning techniques can be proposed in solving this global epidemic.
Eindhoven University of Technology（埃因霍温理工大学）；Maastricht University Medical Center+（马斯特里赫特大学医学中心+）
Type 2 Diabetes (T2D) is a chronic metabolic disorder that can lead to blindness and cardiovascular disease. Information about early stage T2D might be present in retinal fundus images, but to what extent these images can be used for a screening setting is still unknown. In this study, deep neural networks were employed to differentiate between fundus images from individuals with and without T2D. We investigated three methods to achieve high classification performance, measured by the area under the receiver operating curve (ROC-AUC). A multi-target learning approach to simultaneously output r…
Diabetic Retinopathy (DR) is a retinal disorder that affects the people having diabetes mellitus for a long time (20 years). DR is one of the main reasons for the preventable blindness all over the world. If not detected early the patient may progress to severe stages of irreversible blindness. Lack of Ophthalmologists poses a serious problem for the growing diabetes patients. It is advised to develop an automated DR screening system to assist the Ophthalmologist in decision making. Hard exudates develop when DR is present. It is important to detect hard exudates in order to detect DR in an ea…
Detecting diabetic retinopathy severity through fundus images using an ensemble of classifiers
Technical University of Cluj-Napoca（克卢日-纳波卡技术大学）；“Iuliu Hatieganu” University of Medicine and Pharmacy（“尤利乌·哈采加努”医药大学）；Emergency County Hospital（急诊县医院）
HyMNet: a Multimodal Deep Learning System for Hypertension Classification using Fundus Photographs and Cardiometabolic Risk Factors
King Abdullah International Medical Research Center（阿卜杜拉国王国际医学研究中心）；King Saud bin Abdulaziz University for Health Sciences（沙特·本·阿卜杜勒阿齐兹国王健康科学大学）；King Abdulaziz Medical City, Ministry of National Guard Health Affairs（国民警卫队卫生事务部阿卜杜勒阿齐兹国王医疗城）；Prince Mohammad bin Abdulaziz Hospital, Ministry of National Guard Health Affairs（国民警卫队卫生事务部穆罕默德·本·阿卜杜勒阿齐兹亲王医院）
Universidad Nacional de Colombia（哥伦比亚国立大学）；Fundación Oftalmológica Nacional（国家眼科基金会）；Universidad del Rosario（罗萨里奥大学）
Diabetic retinopathy (DR) is the result of a complication of diabetes affecting the retina. It can cause blindness, if left undiagnosed and untreated. An ophthalmologist performs the diagnosis by screening each patient and analyzing the retinal lesions via ocular imaging. In practice, such analysis is time-consuming and cumbersome to perform. This paper presents a model for automatic DR classification on eye fundus images. The approach identifies the main ocular lesions related to DR and subsequently diagnoses the illness. The proposed method follows the same workflow as the clinicians, provid…
FAU Erlangen-Nuremberg（埃尔朗根-纽伦堡大学）；University of Leeds（利兹大学）
Comparison of microvascular circulation on fundoscopic images is a non-invasive clinical indication for the diagnosis and monitoring of diseases, such as diabetes and hypertensions. The differences between intra-patient images can be assessed quantitatively by registering serial acquisitions. Due to the variability of the images (i.e. contrast, luminosity) and the anatomical changes of the retina, the registration of fundus images remains a challenging task. Recently, several deep learning approaches have been proposed to register fundus images in an end-to-end fashion, achieving remarkable re…
Cross-Fundus Transformer for Multi-modal Diabetic Retinopathy Grading with Cataract
Academy for Engineering and Technology, Fudan University（复旦大学工程技术研究院）；School of Computer Science, Fudan University（复旦大学计算机科学技术学院）；Shanghai Eye Diseases Prevention & Treatment Center（上海眼病防治中心）；Shanghai Jiao Tong University School of Medicine（上海交通大学医学院）
Heritage Institute of Technology（遗产理工学院）；Tata Consultancy Services（塔塔咨询服务公司）
Diabetic Retinopathy (DR) is a complication of long-standing, unchecked diabetes and one of the leading causes of blindness in the world. This paper focuses on improved and robust methods to extract some of the features of DR, viz. Blood Vessels and Exudates. Blood vessels are segmented using multiple morphological and thresholding operations. For the segmentation of exudates, k-means clustering and contour detection on the original images are used. Extensive noise reduction is performed to remove false positives from the vessel segmentation algorithm's results. The localization of Optic Disc …
Visulytix Ltd（维视利泰有限公司）；Instituto Mexicano de Oftalmología（墨西哥眼科研究所）；Instituto de la Retina del Bajío（巴希奥视网膜研究所）；Mater Dei Hospital（圣母医院）；King’s College Hospital NHS Foundation Trust（国王学院医院国民保健信托基金）
Objectives: To evaluate the performance of an Artificial Intelligence (AI) system (Pegasus, Visulytix Ltd., UK), at the detection of Diabetic Retinopathy (DR) from images captured by a handheld portable fundus camera. Methods: A cohort of 6,404 patients (~80% with diabetes mellitus) was screened for retinal diseases using a handheld portable fundus camera (Pictor Plus, Volk Optical Inc., USA) at the Mexican Advanced Imaging Laboratory for Ocular Research. The images were graded for DR by specialists according to the Scottish DR grading scheme. The performance of the AI system was evaluated, re…
Purpose: To demonstrate that retinal microvasculature per se is a reliable biomarker for Diabetic Retinopathy (DR) and, by extension, cardiovascular diseases. Methods: Deep Learning Convolutional Neural Networks (CNN) applied to color fundus images for semantic segmentation of the blood vessels and severity classification on both vascular and full images. Vessel reconstruction through harmonic descriptors is also used as a smoothing and de-noising tool. The mathematical background of the theory is also outlined. Results: For diabetic patients, at least 93.8% of DR No-Refer vs. Refer classifica…
Netaji Subhas Institute of Technology（内塔吉·苏巴斯技术学院）；Pandit Deendayal Energy University（潘迪特·迪恩达亚尔能源大学）；National Institute of Technology Delhi（德里国立理工学院）；AMC MET Medical College（AMC MET医学院）
Patients with long-standing diabetes often fall prey to Diabetic Retinopathy (DR) resulting in changes in the retina of the human eye, which may lead to loss of vision in extreme cases. The aim of this study is two-fold: (a) create deep learning models that were trained to grade degraded retinal fundus images and (b) to create a browser-based application that will aid in diagnostic procedures by highlighting the key features of the fundus image. In this research work, we have emulated the images plagued by distortions by degrading the images based on multiple different combinations of Light Tr…
Aalto University School of Science（阿尔托大学理学院）；Digifundus Ltd.（Digifundus有限公司）；Central Finland Central Hospital（中芬兰中心医院）
Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening. This labor-intensive task could greatly benefit from automatic detection using deep learning technique. Here we present a deep learning system that identifies referable diabetic retinopathy comparably or better than presented in the previous studies, although we use only a small fraction of images (<1/4) in training but are aided with higher image resolutions. We also …
DRStageNet: Deep Learning for Diabetic Retinopathy Staging from Fundus Images
Technion, Israel Institute of Technology（以色列理工学院）；Massachusetts Institute of Technology（麻省理工学院）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Harvard T.H. Chan School of Public Health（哈佛大学陈曾熙公共卫生学院）；São Paulo Federal University（圣保罗联邦大学）
National Institute of Technology Karnataka（卡纳塔克邦国家技术研究所）
Diabetic retinopathy (DR) is a severe complication of diabetes that can cause permanent blindness. Timely diagnosis and treatment of DR are critical to avoid total loss of vision. Manual diagnosis is time consuming and error-prone. In this paper, we propose a novel deep learning based method for automatic screening of retinal fundus images to detect and classify DR based on the severity. The method uses a dual-path configuration of deep neural networks to achieve the objective. In the first step, a modified UNet++ based retinal vessel segmentation is used to create a fundus image that emphasis…
Among the most impactful diabetic complications are diabetic retinopathy, the leading cause of blindness among working class adults, and cardiovascular disease, the leading cause of death worldwide. This study describes the development of improved machine learning based screening of these conditions. First, a random forest model was developed by retrospectively analyzing the influence of various risk factors (obtained quickly and non-invasively) on cardiovascular risk. Next, a deep-learning model was developed for prediction of diabetic retinopathy from retinal fundus images by a modified and …
Machine Learning Prediction of Cardiovascular Risk in Type 1 Diabetes Mellitus Using Radiomics Features from Multimodal Retinal Images
Universitat Politècnica de Catalunya (UPC)（加泰罗尼亚理工大学）；Institut Clínic d´Oftalmología (ICOF)（眼科临床研究所）；Hospital Clínic de Barcelona（巴塞罗那临床医院）；Intelligent Data Science and Artificial Intelligence (IDEAI-UPC) Research Center（智能数据科学与人工智能研究中心）；August Pi i Sunyer Biomedical Research Institute (IDIBAPS)（奥古斯特·皮伊·苏涅尔生物医学研究所）；School of Medicine, Universitat de Barcelona（巴塞罗那大学医学院）
Deploying and Evaluating Multiple Deep Learning Models on Edge Devices for Diabetic Retinopathy Detection
Ghana Communication Technology University（加纳通信技术大学）；Council for Scientific and Industrial Research（科学与工业研究委员会）；Shenzhen Technology University（深圳技术大学）；Kwame Nkrumah University of Science and Technology（夸梅·恩克鲁玛科技大学）
Department of Computer Science University of Massachusetts Lowell（马萨诸塞大学洛厄尔分校计算机科学系）；Department of Ophthalmology Central South University（中南大学湘雅医学院（注：原文仅显示Department of Ophthalmology，此处“Central South University”为大学，按要求提取到大学级别））
Diabetic retinopathy (DR) is a primary cause of blindness in working-age people worldwide. About 3 to 4 million people with diabetes become blind because of DR every year. Diagnosis of DR through color fundus images is a common approach to mitigate such problem. However, DR diagnosis is a difficult and time consuming task, which requires experienced clinicians to identify the presence and significance of many small features on high resolution images. Convolutional Neural Network (CNN) has proved to be a promising approach for automatic biomedical image analysis recently. In this work, we inves…
