StudyU：设计和实施创新数字N-of-1试验的平台
StudyU: a platform for designing and conducting innovative digital N-of-1 trials
摘要：
N-of-1试验是评价个体治疗效果和得出个性化治疗策略的金标准研究设计。数字化工具有可能在规模和范围上开创一个N-1试验的新时代，但功能齐全的平台尚未推出。在这里，我们介绍了开源StudyU平台，其中包括StudyU设计器和StudyU应用程序。通过StudyU设计器，科学家可以获得一个协作Web应用程序，以数字方式指定，发布和进行N-of-1试验。StudyU应用程序是一款智能手机应用程序，具有创新的以用户为中心的元素，供参与者参与已发表的试验，并评估不同干预措施对其健康的影响。因此，StudyU平台允许全球的临床医生和研究人员以安全的方式轻松设计和进行数字化N-of-1试验。我们设想StudyU可以改变患者和健康个体的个性化治疗的前景，民主化和个性化的自我优化和医学证据生成，并可以整合到临床实践中。
英文摘要：
N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive personalized treatment strategies. Digital tools have the potential to initiate a new era of N-of-1 trials in terms of scale and scope, but fully-functional platforms are not yet available. Here, we present the open source StudyU platform which includes the StudyU designer and StudyU app. With the StudyU designer, scientists are given a collaborative web application to digitally specify, publish, and conduct N-of-1 trials. The StudyU app is a smartphone application with innovative user-centric elements for participants to partake in the published trials and assess the effects of different interventions on their health. Thereby, the StudyU platform allows clinicians and researchers worldwide to easily design and conduct digital N-of-1 trials in a safe manner. We envision that StudyU can change the landscape of personalized treatments both for patients and healthy individuals, democratize and personalize evidence generation for self-optimization and medicine, and can be integrated in clinical practice.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
