Performing coarse-to-fine abdominal multi-organ segmentation facilitates to extract high-resolution segmentation minimizing the lost of spatial contextual information. However, current coarse-to-refine approaches require a significant number of models to perform single organ refine segmentation corresponding to the extracted organ region of interest (ROI). We propose a coarse-to-fine pipeline, which starts from the extraction of the global prior context of multiple organs from 3D volumes using a low-resolution coarse network, followed by a fine phase that uses a single refined model to segment all abdominal organs instead of multiple organ corresponding models. We combine the anatomical prior with corresponding extracted patches to preserve the anatomical locations and boundary information for performing high-resolution segmentation across all organs in a single model. To train and evaluate our method, a clinical research cohort consisting of 100 patient volumes with 13 organs well-annotated is used. We tested our algorithms with 4-fold cross-validation and computed the Dice score for evaluating the segmentation performance of the 13 organs. Our proposed method using single auto-context outperforms the state-of-the-art on 13 models with an average Dice score 84.58% versus 81.69% (p<0.0001).
PAII Inc.（PAII公司）；The First Affiliated Hospital Zhejiang University（浙江大学附属第一医院）；Johns Hopkins University（约翰斯·霍普金斯大学）；Ping An Insurance Company of China（中国平安保险（集团）股份有限公司）；Zhejiang Provincial People’s Hospital（浙江省人民医院）
Lymph node station (LNS) delineation from computed tomography (CT) scans is an indispensable step in radiation oncology workflow. High inter-user variabilities across oncologists and prohibitive laboring costs motivated the automated approach. Previous works exploit anatomical priors to infer LNS based on predefined ad-hoc margins. However, without voxel-level supervision, the performance is severely limited. LNS is highly context-dependent - LNS boundaries are constrained by anatomical organs - we formulate it as a deep spatial and contextual parsing problem via encoded anatomical organs. Thi…
Université Côte d’Azur（蔚蓝海岸大学）；Inria（法国国家信息与自动化研究所）；Centre Antoine Lacassagne（安托万·拉卡桑中心）
Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for segmentation of organs at risk inside the brain region, from Magnetic Resonance (MR) images. Our system performs segmentation of eight structures: eye, lens, optic nerve, optic chiasm, pituitary gland, hippocampus, brainstem and brain. We propose an efficient algorithm to train neural networks for an end-to-end segmentation of multiple and non-exclusive class…
Two-View Topogram-Based Anatomy-Guided CT Reconstruction for Prospective Risk Minimization
Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)（埃尔朗根-纽伦堡大学模式识别实验室）；Division of X-Ray Imaging and Computed Tomography, German Cancer Research Center (DKFZ)（德国癌症研究中心X射线成像与计算机断层扫描部门）；Department of Physics and Astronomy, Ruprecht-Karls-University Heidelberg（海德堡大学物理与天文学系）；Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)（埃尔朗根-纽伦堡大学埃尔朗根大学医院放射肿瘤科）；Department of Radiology and Nuclear Medicine, Klinikum Nürnberg, Paracelsus Medical University（帕拉塞尔苏斯医科大学纽伦堡医院放射与核医学科）
AG-CRC: Anatomy-Guided Colorectal Cancer Segmentation in CT with Imperfect Anatomical Knowledge
Shanghai Artificial Intelligence Laboratory（上海人工智能实验室）；Shanghai Digital Medicine Innovation Center（上海数字医学创新中心）；Ruijin Hospital（瑞金医院）；Shanghai Jiao Tong University School of Medicine（上海交通大学医学院）
Devil is in Details: Locality-Aware 3D Abdominal CT Volume Generation for Self-Supervised Organ Segmentation
National Engineering Research Center for Multimedia Software（多媒体软件国家工程研究中心）；Hubei Key Laboratory of Multimedia and Network Communication Engineering（湖北省多媒体与网络通信工程重点实验室）；Institute of Artificial Intelligence（人工智能研究院）；School of Computer Science（计算机科学学院）
seg2med: a bridge from artificial anatomy to multimodal medical images
Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University（计算机辅助临床医学，曼海姆医学院，海德堡大学）；Pattern Recognition Lab, Friedrich-Alexander-University Erlangen-Nuremberg（模式识别实验室，埃尔兰根-纽伦堡弗里德里希-亚历山大大学）；Department of Radiology and Nuclear Medicine, University Medical Center Mannheim（放射学与核医学系，曼海姆大学医学中心）；Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University（曼海姆智能医学研究所，曼海姆医学院，海德堡大学）；Optical Bioimaging Laboratory, Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore（光学生物成像实验室，生物医学工程系，设计与工程学院，新加坡国立大学）
Anatomy-constrained modelling of image-derived input functions in dynamic PET using multi-organ segmentation
Department of diagnostic and interventional Radiology and Neuroradiology, University Hospital Augsburg（诊断与介入放射学及神经放射学系，奥格斯堡大学医院）；Computer-Aided Medical Procedures and Augmented Reality, Technical University of Munich（计算机辅助医疗程序与增强现实，慕尼黑技术大学）；Digital Medicine, University Hospital Augsburg（数字医学，奥格斯堡大学医院）；Center of Advanced Analytics and Predictive Sciences, University of Augsburg（高级分析与预测科学中心，奥格斯堡大学）
We hypothesize that probabilistic voxel-level classification of anatomy and malignancy in prostate MRI, although typically posed as near-identical segmentation tasks via U-Nets, require different loss functions for optimal performance due to inherent differences in their clinical objectives. We investigate distribution, region and boundary-based loss functions for both tasks across 200 patient exams from the publicly-available ProstateX dataset. For evaluation, we conduct a thorough comparative analysis of model predictions and calibration, measured with respect to multi-class volume segmentat…
ShanghaiTech University（上海科技大学）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能科技有限公司）；Shanghai Clinical Research and Trial Center（上海临床研究中心）
Image registration of liver dynamic contrast-enhanced computed tomography (DCE-CT) is crucial for diagnosis and image-guided surgical planning of liver cancer. However, intensity variations due to the flow of contrast agents combined with complex spatial motion induced by respiration brings great challenge to existing intensity-based registration methods. To address these problems, we propose a novel structure-aware registration method by incorporating structural information of related organs with segmentation-guided deep registration network. Existing segmentation-guided registration methods …
As lung cancer evolves, the presence of enlarged and potentially malignant lymph nodes must be assessed to properly estimate disease progression and select the best treatment strategy. Following the clinical guidelines, estimation of short-axis diameter and mediastinum station are paramount for correct diagnosis. A method for accurate and automatic segmentation is hence decisive for quantitatively describing lymph nodes. In this study, the use of 3D convolutional neural networks, either through slab-wise schemes or the leveraging of downsampled entire volumes, is investigated. Furthermore, the…
Multi-planar 2D-U-Net Segmentation of 3D-CT Abdominal Organs augmented by Spatial Occurrence Maps
Glasgow Caledonian University School of Science & Engineering（格拉斯哥卡里多尼亚大学科学与工程学院）；Jade University of Applied Sciences Department of Engineering & Medical Technology（雅德应用科学大学工程与医疗技术系）
In nuclear imaging, limited resolution causes partial volume effects (PVEs) that affect image sharpness and quantitative accuracy. Partial volume correction (PVC) methods incorporating high-resolution anatomical information from CT or MRI have been demonstrated to be effective. However, such anatomical-guided methods typically require tedious image registration and segmentation steps. Accurately segmented organ templates are also hard to obtain, particularly in cardiac SPECT imaging, due to the lack of hybrid SPECT/CT scanners with high-end CT and associated motion artifacts. Slight mis-regist…
PromptForSegCXR: Prompt-Driven Multi-Organ and Multi-Disease Segmentation in Chest X-rays using a Multi-stage Fusion Mechanism
1 ,5Department of Computer Science \& Engineering,\ University of Engineering \& Technology, Rajshahi-6204, Bangladesh；2 Department of Electrical；Electronic Engineering,\ University of Engineering；Bachelor of Surgery,\ Suhrawardy Medical College , Sher-E-Bangla Nagar, Dhaka-1207；6 Department of Biomedical Engineering,\ University of Engineering
SP-DiffDose: A Conditional Diffusion Model for Radiation Dose Prediction Based on Multi-Scale Fusion of Anatomical Structures, Guided by SwinTransformer and Projector
University of the Chinese Academy of Sciences（中国科学院大学）；West China Hospital, Sichuan University（四川大学华西医院）；Sichuan University（四川大学）
Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）；Georgia Institute of Technology（佐治亚理工学院）
Thoracic disease detection from chest radiographs using deep learning methods has been an active area of research in the last decade. Most previous methods attempt to focus on the diseased organs of the image by identifying spatial regions responsible for significant contributions to the model's prediction. In contrast, expert radiologists first locate the prominent anatomical structures before determining if those regions are anomalous. Therefore, integrating anatomical knowledge within deep learning models could bring substantial improvement in automatic disease classification. Motivated by …
A Study of Anatomical Priors for Deep Learning-Based Segmentation of Pheochromocytoma in Abdominal CT
Imaging Biomarkers and Computer-Aided Diagnosis Laboratory（影像生物标记与计算机辅助诊断实验室）；Clinical Center, NIH（国家卫生研究院临床中心）；Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH（欧尼丝·凯蒂·施里弗国家儿童健康与人类发展研究所，国家卫生研究院）；National Cancer Institute, NIH（国家癌症研究所，国家卫生研究院）；National Institute of Diabetes and Digestive and Kidney Diseases, NIH（国家糖尿病、消化系统与肾病研究所，国家卫生研究院）
CLIP-Driven Universal Model for Organ Segmentation and Tumor Detection
City University of Hong Kong（香港城市大学）；Johns Hopkins University（约翰斯·霍普金斯大学）；Vanderbilt University（范德堡大学）；Chinese University of Hong Kong（香港中文大学）；CUHK Shenzhen Research Institute（香港中文大学深圳研究院）；NVIDIA（英伟达公司）
Cancer Hospital of University of the Chinese Academy of Sciences (Zhejiang Cancer Hospital)（中国科学院大学附属肿瘤医院（浙江省肿瘤医院））；Rutgers University（罗格斯大学）；The Chinese University of Hong Kong（香港中文大学）；SenseTime Research（商汤科技研究院）
Radiotherapy is a treatment where radiation is used to eliminate cancer cells. The delineation of organs-at-risk (OARs) is a vital step in radiotherapy treatment planning to avoid damage to healthy organs. For nasopharyngeal cancer, more than 20 OARs are needed to be precisely segmented in advance. The challenge of this task lies in complex anatomical structure, low-contrast organ contours, and the extremely imbalanced size between large and small organs. Common segmentation methods that treat them equally would generally lead to inaccurate small-organ labeling. We propose a novel two-stage de…
A Two-Stage Deep Learning Framework for Segmentation of Ten Gastrointestinal Organs from Coronal MR Enterography
Department of Biomedical Physics and Technology, University of Dhaka（达卡大学生物医学物理与技术系）；Department of Biomedical Engineering, Jashore University of Science and Technology（贾沙尔大学科学与技术学院生物医学工程系）；Department of Radiology, Hamad Medical Corporation（哈马德医疗集团放射科）；Department of Electrical Engineering, Qatar University（卡塔尔大学电气工程系）
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）
Non-contrast computed tomography (NCCT) is commonly acquired for lung cancer screening, assessment of general abdominal pain or suspected renal stones, trauma evaluation, and many other indications. However, the absence of contrast limits distinguishing organ in-between boundaries. In this paper, we propose a novel unsupervised approach that leverages pairwise contrast-enhanced CT (CECT) context to compute non-contrast segmentation without ground-truth label. Unlike generative adversarial approaches, we compute the pairwise morphological context with CECT to provide teacher guidance instead of…
Swinburne University of Technology（斯威本科技大学）；Victoria University（维多利亚大学）；Kyung Hee University（庆熙大学）
Quantitative assessment of the abdominal region from clinically acquired CT scans requires the simultaneous segmentation of abdominal organs. Thanks to the availability of high-performance computational resources, deep learning-based methods have resulted in state-of-the-art performance for the segmentation of 3D abdominal CT scans. However, the complex characterization of organs with fuzzy boundaries prevents the deep learning methods from accurately segmenting these anatomical organs. Specifically, the voxels on the boundary of organs are more vulnerable to misprediction due to the highly-va…
