Describing the Structural Phenotype of the Glaucomatous Optic Nerve Head Using Artificial Intelligence

Clinically Verified Hybrid Deep Learning System for Retinal Ganglion Cells Aware Grading of Glaucomatous Progression

Objective: Glaucoma is the second leading cause of blindness worldwide. Glaucomatous progression can be easily monitored by analyzing the degeneration of retinal ganglion cells (RGCs). Many researchers have screened glaucoma by measuring cup-to-disc ratios from fundus and optical coherence tomography scans. However, this paper presents a novel strategy that pays attention to the RGC atrophy for screening glaucomatous pathologies and grading their severity. Methods: The proposed framework encompasses a hybrid convolutional network that extracts the retinal nerve fiber layer, ganglion cell with …

Deep Learning based Framework for Automatic Diagnosis of Glaucoma based on analysis of Focal Notching in the Optic Nerve Head

Automatic evaluation of the retinal fundus image is emerging as one of the most important tools for early detection and treatment of progressive eye diseases like Glaucoma. Glaucoma results to a progressive degeneration of vision and is characterized by the deformation of the shape of optic cup and the degeneration of the blood vessels resulting in the formation of a notch along the neuroretinal rim. In this paper, we propose a deep learning-based pipeline for automatic segmentation of optic disc (OD) and optic cup (OC) regions from Digital Fundus Images (DFIs), thereby extracting distinct fea…

AxoNet: an AI-based tool to count retinal ganglion cell axons

Goal: In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in images of optic nerve tissue from various animal models of glaucoma. Methods: The U-Net convolutional neural network architecture was adapted to learn pixelwise axon count density estimates, which were then integrated over the image area to determine axon counts. The tool, termed AxoNet, was trained and evaluated using a dataset containing images of optic nerve regions randomly selected from complete cross sections of intact rat optic nerves and manually annotated for a…

青光眼与近视交叉点的视神经乳头三维结构表型——改善近视人群青光眼诊断的关键

3D Structural Phenotype of the Optic Nerve Head at the Intersection of Glaucoma and Myopia -- A Key to Improving Glaucoma Diagnosis in Myopic Populations

本研究利用OCT三维点云和集成网络，揭示了健康、高度近视、青光眼及高度近视合并青光眼四种状态下视神经乳头的不同结构表型，为改善近视人群青光眼诊断提供了关键依据。

Glaucoma Detection From Raw Circumapillary OCT Images Using Fully Convolutional Neural Networks

Nowadays, glaucoma is the leading cause of blindness worldwide. We propose in this paper two different deep-learning-based approaches to address glaucoma detection just from raw circumpapillary OCT images. The first one is based on the development of convolutional neural networks (CNNs) trained from scratch. The second one lies in fine-tuning some of the most common state-of-the-art CNNs architectures. The experiments were performed on a private database composed of 93 glaucomatous and 156 normal B-scans around the optic nerve head of the retina, which were diagnosed by expert ophthalmologists…

Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis

Purpose: To evaluate nerve fiber layer (NFL) reflectance for glaucoma diagnosis. Methods: Participants were imaged with 4.5X4.5-mm volumetric disc scans using spectral-domain optical coherence tomography (OCT). The normalized NFL reflectance map was processed by an azimuthal filter to reduce directional reflectance bias due to variation of beam incidence angle. The peripapillary area of the map was divided into 160 superpixels. Average reflectance was the mean of superpixel reflectance. Low-reflectance superpixels were identified as those with NFL reflectance below the 5 percentile normative c…