改善它或失去它：表达竞争的进化成本
Improve it or lose it: evolvability costs of competition for expression
摘要：
已知表达水平是蛋白质进化速率的强决定因素。但反过来也可能是正确的：演化动力学可以影响蛋白质的表达水平。在两个方向上都有影响会促进反馈回路的可能性，其中表达更高的系统更有可能改进并表达得更高，而那些表达较少的系统最终会失去漂移。使用一个最小的模型来研究这一点的背景下，不断变化的环境中，我们证明了这样一个反馈回路的一个意想不到的后果是，一个缓慢的切换到一个新的环境可以让基因型达到更高的健身比直接暴露于它。
英文摘要：
Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of proteins. Having implications in both directions fosters the possibility of a feedback loop, where higher expressed systems are more likely to improve and be expressed even higher, while those that are expressed less are eventually lost to drift. Using a minimal model to study this in the context of a changing environment, we demonstrate that one unexpected consequence of such a feedback loop is that a slow switch to a new environment can allow genotypes to reach higher fitness sooner than a direct exposure to it.
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