构象对DNA TATA-box变形的影响
Conformational impact on deformation of DNA TATA-box
AI总结：
针对DNA TATA-box的异常变形无法用标准WLC模型解释的问题，提出包含糖环构象重排、序列效应等特征的模型，基于双螺旋内部结构特性解释其变形机制。
摘要：
本文对DNA双螺旋特殊序列TATA-box的可变形性开展了理论研究。论文详细阐述了DNA TATA-box双螺旋的异常变形机制，该机制无法用标准高分子分子力学模型（WLC，蠕虫状链）解释，需要更精细的建模。对DNA TATA-box变形的分析表明，该分子可因结构多态性（即双螺旋片段存在多种构象的可能性）发生显著变形。除弹性分量（弯曲、扭转）外，所提出的模型还包含以下变形特征：糖环形状发生构象重排的可能性、特定核苷酸序列与各向异性的效应、各分量之间的耦合。该模型能够基于双螺旋内部结构的物理特性解释异常变形现象。
英文摘要：
The theoretical study of deformability of special sequence of DNA double helix TATA-box is presentated. The paper elaborates on the mechanisms of abnormal deformation of DNA TATA-box double helix that cannot be explained using the standard mechanical model of polymer molecules (WLC) and needs more detailed modeling. Analyzing of DNA TATA-box deformation it is shown the molucule can undergo significant deformations due to its property of the structural polymorphism, that is, possibility of the double helix fragment to exist in more then one conformations. In addition to elastic components (bending, twisting), the presented model includes the following deformation features: possibility of conformation rearrangement of the shapes of the sugar rings, effects of a specific nucleotide sequence and anisotropy, the coupling between components. Presented model allows describe abnormal deformation based on physical special fitures of double helix inner structure.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
