时间常数域光谱：一种基于阻抗的悬浮生物细胞传感方法
Time-Constant-Domain Spectroscopy: An Impedance-based Method for Sensing Biological Cells in Suspension
摘要：
阻抗测量是表征和检测生物细胞电特性的常用技术。然而，为了解码潜在的物理过程，它需要复杂的电气模型以及所研究样品的先验知识。在这项工作中，我们介绍了一个有吸引力的无标记的方法，用于传感悬浮液中的生物细胞的电阻抗测量和弛豫时间分布（DRT）模型的基础上。DRT将阻抗数据从频域映射到时间常数域频谱（TCDS），是数据分析的有用且稳健的方法。我们在1 kHz至1 MHz的范围内进行阻抗测量，以获得用于感测模拟样品以及悬浮液中的HeLa细胞的TCDS。结果表明，TCDS可以被视为样品的电指纹，因为它可以以高灵敏度和分辨率解码关于组成和结构的有用信息。
英文摘要：
Impedance measurement is a common technique to characterize and detect the electrical properties of biological cells. However, to decode the underlying physical processes, it requires complex electrical models alongside prior knowledge of the sample under study. In this work, we introduce an attractive label-free method for sensing biological cells in suspension based on the measurement of electrical impedance and the distribution of relaxation times (DRT) model. The DRT maps impedance data from the frequency-domain to a time-constant-domain spectrum (TCDS) being a useful and robust method for data analysis. We perform impedance measurements in the range from 1 kHz to 1 MHz to obtain the TCDS for sensing mimic samples as well as HeLa cells in suspension. Results show that the TCDS can be seen as an electrical fingerprint for the sample, as it can decode useful information about the composition and structure with high sensitivity and resolution.
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