剪切速率和表面化学对微缝隙血栓形成的影响
Influence of shear rate and surface chemistry on thrombus formation in micro-crevice
摘要：
血栓栓塞并发症仍然是机械循环支持患者管理的中心问题。尽管在现代心室辅助装置的设计和制造中采用了最佳实践，但这些系统的复杂性和模块化性质通常在流动路径中引入内部台阶和裂缝，其可用作血栓形成的病灶。血栓形成可能性受多种因素影响，包括生物材料的流动和表面化学特性。本研究探讨了这些元素的设置中的血流在微裂缝使用多成分的血栓形成的数值模型。模拟再现了实验观察到的血小板沉积模式，并阐明了流动，剪切速率和表面化学在形成沉积中的作用。研究结果为血液接触器械的设计和操作提供了参考。
英文摘要：
Thromboembolic complications remain a central issue in management of patients on mechanical circulatory support. Despite the best practices employed in design and manufacturing of modern ventricular assist devices, complexity and modular nature of these systems often introduces internal steps and crevices in the flow path which can serve as nidus for thrombus formation. Thrombotic potential is influenced by multiple factors including the characteristics of the flow and surface chemistry of the biomaterial. This study explored these elements in the setting of blood flow over a micro-crevice using a multi-constituent numerical model of thrombosis. The simulations reproduced the platelet deposition patterns observed experimentally and elucidated the role of flow, shear rate, and surface chemistry in shaping the deposition. The results offer insights for design and operation of blood-contacting devices.
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