This paper analyzes the effect of a discrete treatment Z on a duration T. The treatment is not randomly assigned. The confounding issue is treated using a discrete instrumental variable explaining the treatment and independent of the error term of the model. Our framework is nonparametric and allows for random right censoring. This specification generates a nonlinear inverse problem and the average treatment effect is derived from its solution. We provide local and global identification properties that rely on a nonlinear system of equations. We propose an estimation procedure to solve this system and derive rates of convergence and conditions under which the estimator is asymptotically normal. When censoring makes identification fail, we develop partial identification results. Our estimators exhibit good finite sample properties in simulations. We also apply our methodology to the Illinois Reemployment Bonus Experiment.
Many applications involve a censored dependent variable and an endogenous independent variable. Chernozhukov et al. (2015) introduced a censored quantile instrumental variable estimator (CQIV) for use in those applications, which has been applied by Kowalski (2016), among others. In this article, we introduce a Stata command, cqiv, that simplifes application of the CQIV estimator in Stata. We summarize the CQIV estimator and algorithm, we describe the use of the cqiv command, and we provide empirical examples.
This note shows that adding monotonicity or convexity constraints on the regression function does not restore well-posedness in nonparametric instrumental variable regression. The minimum distance problem without regularisation is still locally ill-posed.
The problem of endogeneity in statistics and econometrics is often handled by introducing instrumental variables (IV) which fulfill the mean independence assumption, i.e. the unobservable is mean independent of the instruments. When full independence of IV's and the unobservable is assumed, nonparametric IV regression models and nonparametric demand models lead to nonlinear integral equations with unknown integral kernels. We prove convergence rates for the mean integrated square error of the iteratively regularized Newton method applied to these problems. Compared to related results we derive…
This paper discusses endogenous treatment models with duration outcomes, competing risks and random right censoring. The endogeneity issue is solved using a discrete instrumental variable. We show that the competing risks model generates a non-parametric quantile instrumental regression problem. The cause-specific cumulative incidence, the cause-specific hazard and the subdistribution hazard can be recovered from the regression function. A distinguishing feature of the model is that censoring and competing risks prevent identification at some quantiles. We characterize the set of quantiles for…
This paper considers identification and estimation of the causal effect of the time Z until a subject is treated on a survival outcome T. The treatment is not randomly assigned, T is randomly right censored by a random variable C and the time to treatment Z is right censored by min(T,C). The endogeneity issue is treated using an instrumental variable explaining Z and independent of the error term of the model. We study identification in a fully nonparametric framework. We show that our specification generates an integral equation, of which the regression function of interest is a solution. We …
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and show that they are attained by particular estimators. In the presence of instrumental variables the relation that identifies the regression function also defines an ill-posed inverse problem, the ``difficulty'' of which depends on eigenvalues of a certain integral operator which is determined by the joint density of endogenous and instrumental va…
We study the problem of nonparametric regression when the regressor is endogenous, which is an important nonparametric instrumental variables (NPIV) regression in econometrics and a difficult ill-posed inverse problem with unknown operator in statistics. We first establish a general upper bound on the sup-norm (uniform) convergence rate of a sieve estimator, allowing for endogenous regressors and weakly dependent data. This result leads to the optimal sup-norm convergence rates for spline and wavelet least squares regression estimators under weakly dependent data and heavy-tailed error terms. …
In randomized clinical trials with survival outcome, there has been an increasing interest in subgroup identification based on baseline genomic, proteomic markers or clinical characteristics. Some of the existing methods identify subgroups that benefit substantially from the experimental treatment by directly modeling outcomes or treatment effect. When the goal is to find an optimal treatment for a given patient rather than finding the right patient for a given treatment, methods under the individualized treatment regime framework estimate an individualized treatment rule that would lead to th…
The ill-posedness of the inverse problem of recovering a regression function in a nonparametric instrumental variable model leads to estimators that may suffer from a very slow, logarithmic rate of convergence. In this paper, we show that restricting the problem to models with monotone regression functions and monotone instruments significantly weakens the ill-posedness of the problem. In stark contrast to the existing literature, the presence of a monotone instrument implies boundedness of our measure of ill-posedness when restricted to the space of monotone functions. Based on this result we…
Two problems that arise in making causal inferences for non-mortality outcomes such as bronchopulmonary dysplasia (BPD) are unmeasured confounding and censoring by death, i.e., the outcome is only observed when subjects survive. In randomized experiments with noncompliance, instrumental variable methods can be used to control for the unmeasured confounding without censoring by death. But when there is censoring by death, the average causal treatment effect cannot be identified under usual assumptions, but can be studied for a specific subpopulation by using sensitivity analysis with additional…
The method of instrumental variables provides a fundamental and practical tool for causal inference in many empirical studies where unmeasured confounding between the treatments and the outcome is present. Modern data such as the genetical genomics data from these studies are often high-dimensional. The high-dimensional linear instrumental-variables regression has been considered in the literature due to its simplicity albeit a true nonlinear relationship may exist. We propose a more data-driven approach by considering the nonparametric additive models between the instruments and the treatment…
Arizona State University（亚利桑那州立大学）；Medical College of Wisconsin（威斯康星医学院）
We provide a new flexible framework for inference with the instrumental variable model. Rather than using linear specifications, functions characterizing the effects of instruments and other explanatory variables are estimated using machine learning via Bayesian Additive Regression Trees (BART). Error terms and their distribution are inferred using Dirichlet Process mixtures. Simulated and real examples show that when the true functions are linear, little is lost. But when nonlinearities are present, dramatic improvements are obtained with virtually no manual tuning.
Instrumental variable methods allow for inference about the treatment effect by controlling for unmeasured confounding in randomized experiments with noncompliance. However, many studies do not consider the observed compliance behavior in the testing procedure, which can lead to a loss of power. In this paper, we propose a novel nonparametric likelihood approach, referred to as the binomial likelihood (BL) method, that incorporates information on compliance behavior while overcoming several limitations of previous techniques and utilizing the advantages of likelihood methods. Our proposed meth…
Instrumental variable (IV) methods allow us the opportunity to address unmeasured confounding in causal inference. However, most IV methods are only applicable to discrete or continuous outcomes with very few IV methods for censored survival outcomes. In this work we propose nonparametric estimators for the local average treatment effect on survival probabilities under both nonignorable and ignorable censoring. We provide an efficient influence function-based estimator and a simple estimation procedure when the IV is either binary or continuous. The proposed estimators possess double-robustnes…
University College London（伦敦大学学院）；University of Oxford（牛津大学）；The Alan Turing Institute（艾伦·图灵研究所）
We propose a kernel-based nonparametric estimator for the causal effect when the cause is corrupted by error. We do so by generalizing estimation in the instrumental variable setting. Despite significant work on regression with measurement error, additionally handling unobserved confounding in the continuous setting is non-trivial: we have seen little prior work. As a by-product of our investigation, we clarify a connection between mean embeddings and characteristic functions, and how learning one simultaneously allows one to learn the other. This opens the way for kernel method research to le…
This article introduces a new instrumental variable approach for estimating unknown population parameters with data having nonrandom missing values. With coarse and discrete instruments, Shao and Wang (2016) proposed a semiparametric method that uses the added information to identify the tilting parameter from the missing data propensity model. A naive application of this idea to continuous instruments through arbitrary discretizations is apt to be inefficient, and maybe questionable in some settings. We propose a nonparametric method not requiring arbitrary discretizations but involves scanni…
Instrumental variable (IV) regression is a strategy for learning causal relationships in observational data. If measurements of input X and output Y are confounded, the causal relationship can nonetheless be identified if an instrumental variable Z is available that influences X directly, but is conditionally independent of Y given X and the unmeasured confounder. The classic two-stage least squares algorithm (2SLS) simplifies the estimation problem by modeling all relationships as linear functions. We propose kernel instrumental variable regression (KIV), a nonparametric generalization of 2SL…
Towards a Unified Analysis of Neural Networks in Nonparametric Instrumental Variable Regression: Optimization and Generalization
University College London（伦敦大学学院）；Nanyang Technological University（南洋理工大学）；The University of Tokyo（东京大学）；RIKEN Center for Advanced Intelligence Project（理化学研究所革新智能综合研究中心）
We develop a Bayesian nonparametric (BNP) approach to evaluate the causal effect of treatment in a randomized trial where a nonterminal event may be censored by a terminal event, but not vice versa (i.e., semi-competing risks). Based on the idea of principal stratification, we define a novel estimand for the causal effect of treatment on the nonterminal event. We introduce identification assumptions, indexed by a sensitivity parameter, and show how to draw inference using our BNP approach. We conduct simulation studies and illustrate our methodology using data from a brain cancer trial.
Partial identification approaches are a flexible and robust alternative to standard point-identification approaches in general instrumental variable models. However, this flexibility comes at the cost of a ``curse of cardinality'': the number of restrictions on the identified set grows exponentially with the number of points in the support of the endogenous treatment. This article proposes a novel path-sampling approach to this challenge. It is designed for partially identifying causal effects of interest in the most complex models with continuous endogenous treatments. A stochastic process re…
This paper considers endogenous selection models, in particular nonparametric ones. Estimating the unconditional law of the outcomes is possible when one uses instrumental variables. Using a selection equation which is additively separable in a one dimensional unobservable has the sometimes undesirable property of instrument monotonicity. We present models which allow for nonmonotonicity and are based on nonparametric random coefficients indices. We discuss their nonparametric identification and apply these results to inference on nonlinear statistics such as the Gini index in surveys when the…
Heterogeneous Treatment Effect in Time-to-Event Outcomes: Harnessing Censored Data with Recursively Imputed Trees
Faculty of Data and Decisions Sciences, Technion - Israel Institute of Technology（数据与决策科学学院，技术ion-以色列理工学院）；Department of Statistics and Operations Research, Tel Aviv University（统计与运筹学系，特拉维夫大学）
Censored data, where the event time is partially observed, are challenging for survival probability estimation. In this paper, we introduce a novel nonparametric fiducial approach to interval-censored data, including right-censored, current status, case II censored, and mixed case censored data. The proposed approach leveraging a simple Gibbs sampler has a useful property of being "one size fits all", i.e., the proposed approach automatically adapts to all types of non-informative censoring mechanisms. As shown in the extensive simulations, the proposed fiducial confidence intervals significan…
Uniform inference for kernel instrumental variable regression
Seminar for Statistics, ETH Zurich（苏黎世联邦理工学院统计研讨会）；Society of Fellows and Department of Economics, Harvard University（哈佛大学费利格学会与经济系）；Department of Economics, U.C. San Diego（加州大学圣地亚哥分校经济系）
A number of models for generating statistical data in various fields of insurance, including life insurance, pensions, and general insurance have been considered. It is shown that the insurance statistics data, as a rule, are truncated and censored, and often multivariate. We propose a non-parametric estimation of the distribution function for multivariate truncated-censored data in the form of a quasi-empirical distribution and a simple iterative algorithm for its construction. To check the accuracy of the proposed evaluation of the distribution function for truncated-censored data, simulatio…
In this article, we consider a useful product-limit estimator of distribution function proposed by Huang & Qin(2011) when the observations are subject to length-biased and right-censored data. The estimator retains the simple closed-form expression of the truncation product-limit estimator with some good properties. An almost sure representation for the estimator is obtained which can be used to derive many properties of functional statistics based on this product-limit estimator. The rate for the remainder in the representation is of order $O(n^{-3/4}(\log(n)^{3/4}) $ a.s.
This paper establishes that so-called instrumental variables enable the identification and the estimation of a fully nonparametric regression model with Berkson-type measurement error in the regressors. An estimator is proposed and proven to be consistent. Its practical performance and feasibility are investigated via Monte Carlo simulations as well as through an epidemiological application investigating the effect of particulate air pollution on respiratory health. These examples illustrate that Berkson errors can clearly not be neglected in nonlinear regression models and that the proposed m…
Assume we observe a finite number of inspection times together with information on whether a specific event has occurred before each of these times. Suppose replicated measurements are available on multiple event times. The set of inspection times, including the number of inspections, may be different for each event. This is known as mixed case interval censored data. We consider Bayesian estimation of the distribution function of the event time while assuming it is concave. We provide sufficient conditions on the prior such that the resulting procedure is consistent from the Bayesian point of…
In this paper, we are concerned with nonparametric estimation of the multivariate regression function in the presence of right censored data. More precisely, we propose a statistic that is shown to be asymptotically normally distributed under the additive assumption, and that could be used to test for additivity in the censored regression setting.
This article proposes different tests for treatment effect heterogeneity when the outcome of interest, typically a duration variable, may be right-censored. The proposed tests study whether a policy 1) has zero distributional (average) effect for all subpopulations defined by covariate values, and 2) has homogeneous average effect across different subpopulations. The proposed tests are based on two-step Kaplan-Meier integrals and do not rely on parametric distributional assumptions, shape restrictions, or on restricting the potential treatment effect heterogeneity across different subpopulatio…
Linear transformation model provides a general framework for analyzing censored survival data with covariates. The proportional hazards and proportional odds models are special cases of the linear transformation model. In biomedical studies, covariates with measurement error may occur in survival data. In this work, we propose a method to obtain estimators of the regression coefficients in the linear transformation model when the covariates are subject to measurement error. In the proposed method, we assume that instrumental variables are available. We develop counting process based estimating…
In this paper, we establish uniform-in-bandwidth limit laws of the logarithm for nonparametric Inverse Probability of Censoring Weighted (I.P.C.W.) estimators of the multivariate regression function under random censorship. A similar result is deduced for estimators of the conditional distribution function. The uniform-in-bandwidth consistency for estimators of the conditional density and the conditional hazard rate functions are also derived from our main result. Moreover, the logarithm laws we establish are shown to yield almost sure simultaneous asymptotic confidence bands for the functions…
Let $ (T_i)_i$ be a sequence of independent identically distributed (i.i.d.) random variables (r.v.) of interest distributed as $ T$ and $(X_i)_i$ be a corresponding vector of covariates taking values on $ \mathbb{R}^d$. In censorship models the r.v. $T$ is subject to random censoring by another r.v. $C$. In this paper we built a new kernel estimator based on the so-called synthetic data of the mean squared relative error for the regression function. We establish the uniform almost sure convergence with rate over a compact set and its asymptotic normality. The asymptotic variance is explicitly…
In this paper, we study the local constant and the local linear estimators of the conditional density function with right-censored data which exhibit some type of dependence. It is assumed that the observations form a stationary $α-$mixing sequence. The asymptotic normality of the two estimators is established, which combined with the condition that $\lim\limits_{n\rightarrow\infty}nh_nb_n=\infty$ implies the consistency of the two estimators and can be employed to construct confidence intervals for the conditional density function. The result on the local linear estimator of the conditional d…
