考虑雄性和雌性动物的监管毒理学中体内生物测定的统计学评价
Statistical evaluation of in-vivo bioassays in regulatory toxicology considering males and females
摘要：
雄性和雌性动物的单独评价是使用Dunnett检验进行剂量或处理效应体内毒理学的最新标准。性别-治疗相互作用的替代预检验存在问题。在这里，提出了一个联合测试，考虑到两个性别特异性和合并Dunnett型比较。使用真实数据示例演示了使用R-package multcomp计算同时置信区间或调整的p值。
英文摘要：
The separate evaluation for males and females is the recent standard in in-vivo toxicology for dose or treatment effects using Dunnett tests. The alternative pre-test for sex-by-treatment interaction is problematic. Here a joint test is proposed considering the two sex-specific and the pooled Dunnett-type comparisons. The calculation of either simultaneous confidence intervals or adjusted p-values with the R-package multcomp is demonstrated using a real data example.
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