The ReLU activation function (AF) has been extensively applied in deep neural networks, in particular Convolutional Neural Networks (CNN), for image classification despite its unresolved dying ReLU problem, which poses challenges to reliable applications. This issue has obvious important implications for critical applications, such as those in healthcare. Recent approaches are just proposing variations of the activation function within the same unresolved dying ReLU challenge. This contribution reports a different research direction by investigating the development of an innovative quantum approach to the ReLU AF that avoids the dying ReLU problem by disruptive design. The Leaky ReLU was leveraged as a baseline on which the two quantum principles of entanglement and superposition were applied to derive the proposed Quantum ReLU (QReLU) and the modified-QReLU (m-QReLU) activation functions. Both QReLU and m-QReLU are implemented and made freely available in TensorFlow and Keras. This original approach is effective and validated extensively in case studies that facilitate the detection of COVID-19 and Parkinson Disease (PD) from medical images. The two novel AFs were evaluated in a two-layered CNN against nine ReLU-based AFs on seven benchmark datasets, including images of spiral drawings taken via graphic tablets from patients with Parkinson Disease and healthy subjects, and point-of-care ultrasound images on the lungs of patients with COVID-19, those with pneumonia and healthy controls. Despite a higher computational cost, results indicated an overall higher classification accuracy, precision, recall and F1-score brought about by either quantum AFs on five of the seven bench-mark datasets, thus demonstrating its potential to be the new benchmark or gold standard AF in CNNs and aid image classification tasks involved in critical applications, such as medical diagnoses of COVID-19 and PD.
Signature Activation: A Sparse Signal View for Holistic Saliency
Harvard University（哈佛大学）；Broad Institute of Massachusetts Institute of Technology and Harvard（麻省理工学院与哈佛大学博德研究所）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）
Deep neural networks have been successfully used in diverse emerging domains to solve real world complex problems with may more deep learning(DL) architectures, being developed to date. To achieve these state-of-the-art performances, the DL architectures use activation functions (AFs), to perform diverse computations between the hidden layers and the output layers of any given DL architecture. This paper presents a survey on the existing AFs used in deep learning applications and highlights the recent trends in the use of the activation functions for deep learning applications. The novelty of …
Neural networks have been widely used to solve complex real-world problems. Due to the complicate, nonlinear, non-convex nature of neural networks, formal safety guarantees for the output behaviors of neural networks will be crucial for their applications in safety-critical systems.In this paper, the output reachable set computation and safety verification problems for a class of neural networks consisting of Rectified Linear Unit (ReLU) activation functions are addressed. A layer-by-layer approach is developed to compute output reachable set. The computation is formulated in the form of a set…
Nagoya University（名古屋大学）；Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；National Institute of Informatics（国立信息学研究所）；Keio University School of Medicine（庆应义塾大学医学部）；Juntendo University（顺天堂大学）
This paper presents a fully-automated method for the identification of suspicious regions of a coronavirus disease (COVID-19) on chest CT volumes. One major role of chest CT scanning in COVID-19 diagnoses is identification of an inflammation particular to the disease. This task is generally performed by radiologists through an interpretation of the CT volumes, however, because of the heavy workload, an automatic analysis method using a computer is desired. Most computer-aided diagnosis studies have addressed only a portion of the elements necessary for the identification. In this work, we real…
Ghent University Global Campus（根特大学全球校区）；Ghent University（根特大学）
Glaucoma is a major eye disease, leading to vision loss in the absence of proper medical treatment. Current diagnosis of glaucoma is performed by ophthalmologists who are often analyzing several types of medical images generated by different types of medical equipment. Capturing and analyzing these medical images is labor-intensive and expensive. In this paper, we present a novel computational approach towards glaucoma diagnosis and localization, only making use of eye fundus images that are analyzed by state-of-the-art deep learning techniques. Specifically, our approach leverages Convolution…
Hochschule Pforzheim（普福尔茨海姆应用技术大学）；Smart Data and Knowledge Services German Research Center for Artificial Intelligence GmbH (DFKI)（德国人工智能研究中心智能数据与知识服务部）；Technische Universität Kaiserslautern（凯泽斯劳滕工业大学）；Universitätsklinikum Münster（明斯特大学医院）；Universitätsklinikum Düsseldorf（杜塞尔多夫大学医院）；National University of Science and Technology (NUST)（巴基斯坦国立科技大学）；National Center of Artificial Intelligence（国家人工智能中心）
Deep learning based medical image classifiers have shown remarkable prowess in various application areas like ophthalmology, dermatology, pathology, and radiology. However, the acceptance of these Computer-Aided Diagnosis (CAD) systems in real clinical setups is severely limited primarily because their decision-making process remains largely obscure. This work aims at elucidating a deep learning based medical image classifier by verifying that the model learns and utilizes similar disease-related concepts as described and employed by dermatologists. We used a well-trained and high performing n…
University of Dayton（代顿大学）；University of Dayton Research Institute（代顿大学研究院）
Computer-aided detection has been a research area attracting great interest in the past decade. Machine learning algorithms have been utilized extensively for this application as they provide a valuable second opinion to the doctors. Despite several machine learning models being available for medical imaging applications, not many have been implemented in the real-world due to the uninterpretable nature of the decisions made by the network. In this paper, we investigate the results provided by deep neural networks for the detection of malaria, diabetic retinopathy, brain tumor, and tuberculosi…
Slovak University of Technology（斯洛伐克理工大学）；Johannes Kepler University（约翰内斯·开普勒大学）
In many practical applications, deep neural networks have been typically deployed to operate as a black box predictor. Despite the high amount of work on interpretability and high demand on the reliability of these systems, they typically still have to include a human actor in the loop, to validate the decisions and handle unpredictable failures and unexpected corner cases. This is true in particular for failure-critical application domains, such as medical diagnosis. We present a novel approach to explain and support an interpretation of the decision-making process to a human expert operating…
Computer-Aided Osteoporosis Diagnosis Using Transfer Learning with Enhanced Features from Stacked Deep Learning Modules
Bangladesh Army University of Science and Technology（孟加拉国陆军科技大学）；Brac University（BRAC大学）；National Institute of Textile Engineering and Research (NITER)（国家纺织工程与研究所（NITER））；University of Dhaka（达卡大学）
COVID-19 Infection Map Generation and Detection from Chest X-Ray Images
Tampere University（坦佩雷大学）；Qatar University（卡塔尔大学）；Reem Medical Center（里姆医疗中心）；Hamad Medical Corporation Hospital（哈马德医疗公司医院）；Weill Cornell Medicine - Qatar（威尔康奈尔医学院卡塔尔分校）
Reduced Deep Convolutional Activation Features (R-DeCAF) in Histopathology Images to Improve the Classification Performance for Breast Cancer Diagnosis
Institute of Medical Science and Technology, Shahid Beheshti University（沙希德·贝赫什提大学医学科学与技术研究所）
Explainable artificial intelligence (XAI) is increasingly used to analyze the behavior of neural networks. Concept activation uses human-interpretable concepts to explain neural network behavior. This study aimed at assessing the feasibility of regression concept activation to explain detection and classification of multi-modal volumetric data. Proof-of-concept was demonstrated in metastatic prostate cancer patients imaged with positron emission tomography/computed tomography (PET/CT). Multi-modal volumetric concept activation was used to provide global and local explanations. Sensitivity was …
University of Tübingen（图宾根大学）；Cooperative State University Stuttgart（斯图加特合作州立大学）
Traditionally, for most machine learning settings, gaining some degree of explainability that tries to give users more insights into how and why the network arrives at its predictions, restricts the underlying model and hinders performance to a certain degree. For example, decision trees are thought of as being more explainable than deep neural networks but they lack performance on visual tasks. In this work, we empirically demonstrate that applying methods and architectures from the explainability literature can, in fact, achieve state-of-the-art performance for the challenging task of domain…
National Research Council Canada（加拿大国家研究委员会）；University of Waterloo（滑铁卢大学）；Ford Motor Company（福特汽车公司）
Chest radiography is an effective screening tool for diagnosing pulmonary diseases. In computer-aided diagnosis, extracting the relevant region of interest, i.e., isolating the lung region of each radiography image, can be an essential step towards improved performance in diagnosing pulmonary disorders. Methods: In this work, we propose a deep learning approach to enhance abnormal chest x-ray (CXR) identification performance through segmentations. Our approach is designed in a cascaded manner and incorporates two modules: a deep neural network with criss-cross attention modules (XLSor) for loc…
Swiss Center for Electronics and Microtechnology (CSEM SA)（瑞士电子与微技术中心）
ECG heartbeat classification plays a vital role in diagnosis of cardiac arrhythmia. The goal of the Physionet/CinC 2021 challenge was to accurately classify clinical diagnosis based on 12, 6, 4, 3 or 2-lead ECG recordings in order to aid doctors in the diagnoses of different heart conditions. Transformers have had great success in the field of natural language processing in the past years. Our team, CinCSEM, proposes to draw the parallel between text and periodic time series signals by viewing the repeated period as words and the whole signal as a sequence of such words. In this way, the atten…
Given image labels as the only supervisory signal, we focus on harvesting, or mining, thoracic disease localizations from chest X-ray images. Harvesting such localizations from existing datasets allows for the creation of improved data sources for computer-aided diagnosis and retrospective analyses. We train a convolutional neural network (CNN) for image classification and propose an attention mining (AM) strategy to improve the model's sensitivity or saliency to disease patterns. The intuition of AM is that once the most salient disease area is blocked or hidden from the CNN model, it will pa…
South China University of Technology（华南理工大学）；Ocean University of China（中国海洋大学）；The Hong Kong Polytechnic University（香港理工大学）
Despite the demonstrated editing capacity in the latent space of a pretrained GAN model, inverting real-world images is stuck in a dilemma that the reconstruction cannot be faithful to the original input. The main reason for this is that the distributions between training and real-world data are misaligned, and because of that, it is unstable of GAN inversion for real image editing. In this paper, we propose a novel GAN prior based editing framework to tackle the out-of-domain inversion problem with a composition-decomposition paradigm. In particular, during the phase of composition, we introd…
Advancing Out-of-Distribution Detection through Data Purification and Dynamic Activation Function Design
Aerospace Information Research Institute, Chinese Academy of Sciences（中国科学院空天信息创新研究院）；University of Chinese Academy of Sciences（中国科学院大学）；Zhejiang University（浙江大学）
TU Munich（慕尼黑工业大学）；Universitat Pompeu Fabra（庞培法布拉大学）；Klinikum rechts der Isar（伊萨尔河右岸医院）；Ludwig Maximilian University（路德维希-马克西米利安大学）；CNRS（法国国家科学研究中心）；Ecole Centrale Nantes（南特中央理工学院）；Johns Hopkins University（约翰斯·霍普金斯大学）
In this paper, we target the problem of fracture classification from clinical X-Ray images towards an automated Computer Aided Diagnosis (CAD) system. Although primarily dealing with an image classification problem, we argue that localizing the fracture in the image is crucial to make good class predictions. Therefore, we propose and thoroughly analyze several schemes for simultaneous fracture localization and classification. We show that using an auxiliary localization task, in general, improves the classification performance. Moreover, it is possible to avoid the need for additional localiza…
IIIT Hyderabad（印度理工学院海得拉巴分校（IIIT Hyderabad））；India（印度（注意：根据提取规则，国家“India”不属于机构，此处可能是地址信息，原文本中“Affiliation: IIIT Hyderabad, India, 500032”，主要机构为IIIT Hyderabad，“India”和“500032”为地址相关，按要求不提取，因此仅保留IIIT Hyderabad）}]} 修正：根据规则，机构粒度到大学/学院级别即可，且不要提取国家、城市等。原文本中“Affiliation: IIIT Hyderabad, India, 500032”，核心机构是“IIIT Hyderabad”，印度（India）是国家，不属于机构，因此正确输出应为：{）
Deep learning based approaches to Computer Aided Diagnosis (CAD) typically pose the problem as an image classification (Normal or Abnormal) problem. These systems achieve high to very high accuracy in specific disease detection for which they are trained but lack in terms of an explanation for the provided decision/classification result. The activation maps which correspond to decisions do not correlate well with regions of interest for specific diseases. This paper examines this problem and proposes an approach which mimics the clinical practice of looking for an evidence prior to diagnosis. …
