圆环病毒是否在蝙蝠和穿山甲冠状病毒之间介导了重组，产生了SARS-CoV-2？
Did circoviruses intermediate the recombination between bat and pangolin coronaviruses, yielding SARS-CoV-2?
摘要：
自中国湖北省武汉市首次报告由严重急性呼吸道综合征病毒（SARS-CoV-2）引起的2019冠状病毒（CoV）疾病（COVID-19）以来，科学家们正在夜以继日地寻找其起源问题的合理答案。虽然关于SARS-CoV-2的科学文章数量正在增加，但关于其起源仍然存在许多空白。所有的研究都没有在其他动物身上发现一种冠状病毒，它比蝙蝠病毒更类似于人类SARS-COV 2，而蝙蝠病毒被认为是主要的宿主。在这篇论文中，我们提出了一个新的假设，基于DNA和SARS冠状病毒之间可能的重组，以解释SRAS-CoV-2的崛起。通过比较SARS-CoV-2及相关CoV与圆环病毒（Circoviruses，CV）的序列，发现Bat-CoV ORF 1a基因组3-末端区域与猪圆环病毒2型（PCV 2）的复制起点（origin of replication，Ori）有很强的序列相似性，并且CoV S基因切割位点区域与PCV 2的Ori具有相似的RNA二级结构。这构成了支持可能的重组的主要证据，这种重组的发生可能解释SARS-CoV-2的起源。
英文摘要：
Since the first reports of a coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome virus (SARS-CoV-2) in Wuhan, Hubei province, China, scientists are working around the clock to find sound answers to the issue of its origin. While the number of scientific articles on SARS-CoV-2 is increasing, there are still many gaps as to its origin. All studies failed to find a coronavirus in other animals that is more similar to human SARS-COV2 than the bat virus, considered to be the primary reservoir. In this paper we address a new hypothesis, based on a possible recombination between a DNA and SARS-CoV viruses, to explain the rise of SRAS-CoV-2. By comparing SARS-CoV-2 and related CoVs with circoviruses (CVs), we found strong sequence similarity of the genomic region at the 3-end of Bat-CoV ORF1a and the origin of replication (Ori) of porcine CV type 2 (PCV2), as well as similar RNA secondary structures of the region encompassing the cleavage site of CoV S gene with the PCV2 Ori. This constitutes a primary evidence that supports a possible recombination, which occurrence might explain the origin of SARS-CoV-2.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
