用于组合分析的表面纳米液滴中的集成纳米萃取和比色反应
Integrated nanoextraction and colorimetric reactions in surface nanodroplets for combinative analysis
摘要：
化学分析的组合方法可以在一个步骤中将大量化合物的混合物与其他混合物区分开来。这项工作展示了一种组合分析方法，通过使用表面纳米液滴整合纳米萃取和比色反应，用于识别多组分混合物。模型分析物是溶解在油中的酸性化合物，其被提取到固体基质上的水性液滴中。酸解离产生的质子与液滴内的卤代变色化合物反应，导致液滴的颜色变化。比色反应的速率对酸类型表现出一定的特异性，区分具有相同pH值的酸混合物。其基本原理是酸迁移速率除了与油中的浓度有关外，还与酸的分配系数和离解常数有关。作为示范，我们表明，基于液滴的组合分析可以应用于各种酒类的防伪，通过比较白酒中的有机酸混合物的脱色时间。读数可以通过使用普通的手持移动电话来完成。
英文摘要：
A combinative approach for chemical analysis makes it possible to distinguish a mixture of a large number of compounds from other mixtures in a single step. This work demonstrates a combinative analysis approach by using surface nanodroplets for integrating nanoextraction and colorimetric reactions for the identification of multi-component mixtures. The model analytes are acidic compounds dissolved in oil that are extracted into aqueous droplets on a solid substrate. The proton from acid dissociation reacts with the halochromic chemical compounds inside the droplets, leading to the color change of the droplets. The rate of the colorimetric reaction exhibits certain specificity for the acid type, distinguishing acid mixtures with the same pH value. The underlying principle is that the acid transport rate is associated with the partition coefficient and the dissociation constant of the acid, in addition to the concentration in oil. As a demonstration, we showed that droplet-based combinative analysis can be applied for anti-counterfeiting of various alcoholic spirits by comparing decolor time of organic acid mixtures in the spirits. The readout can be done by using a common hand-hold mobile phone.
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