MOSGA：模块化开源基因组注释器
MOSGA: Modular Open-Source Genome Annotator
摘要：
由于测序技术的最新进展，即使是大型真核生物基因组的高质量组装也已成为许多生物学家的常规任务。然而，这些组装的注释--这是解开感兴趣的生物体生物学的关键一步--仍然是一个复杂的挑战，往往需要先进的生物信息学专业知识。在这里，我们提出了MOSGA，真核生物基因组的基因组注释框架与用户友好的网络界面，生成和集成各种工具的注释。聚合的结果可以用完全集成的基因组浏览器进行分析，并以准备提交给NCBI的格式提供。MOSGA是建立在一个可移植的，可定制的，易于扩展的Snakemake后端，因此，可以定制为广泛的用户和项目。我们在https://mosga.mathematik.uni-marburg.de上提供MOSGA作为公开免费的Web服务，并在registry.gitlab.com/mosga/mosga:latest上提供Docker容器。源代码可以在https://gitlab.com/mosga/mosga上找到
英文摘要：
The generation of high-quality assemblies, even for large eukaryotic genomes, has become a routine task for many biologists thanks to recent advances in sequencing technologies. However, the annotation of these assemblies - a crucial step towards unlocking the biology of the organism of interest - has remained a complex challenge that often requires advanced bioinformatics expertise. Here we present MOSGA, a genome annotation framework for eukaryotic genomes with a user-friendly web-interface that generates and integrates annotations from various tools. The aggregated results can be analyzed with a fully integrated genome browser and are provided in a format ready for submission to NCBI. MOSGA is built on a portable, customizable, and easily extendible Snakemake backend, and thus, can be tailored to a wide range of users and projects. We provide MOSGA as a publicly free available web service at https://mosga.mathematik.uni-marburg.de and as a docker container at registry.gitlab.com/mosga/mosga:latest. Source code can be found at https://gitlab.com/mosga/mosga
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
