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arXiv 2009.02822q-bio.GNmath.CT
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基因组学的应用范畴理论

Applied Category Theory for Genomics -- An Initiative

Yanying Wu

摘要:

地球上所有生命的终极秘密都隐藏在它们的基因组中--DNA序列的总和。我们目前知道许多生物体的整个基因组序列,而我们对系统水平上的基因组结构的理解仍然是初步的。应用范畴理论为整合基因组学中大量的异质信息,推进我们对基因组组织的认识,并为我们提供对自身基因组的深入和全面的看法开辟了一条有前途的道路。在这项工作中,我们解释了为什么应用范畴理论带来了这样的希望,我们继续展示它实际上是如何做到这一点的,尽管是在婴儿阶段。手稿的目的是可读的数学家和生物学家,因此没有事先的知识是需要从任何一方。

英文摘要:

The ultimate secret of all lives on earth is hidden in their genomes -- a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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