自噬体形成过程中膜形态变化的模拟
Modeling membrane morphological change during autophagosome formation
摘要：
自噬是一种由自噬体从头形成介导的细胞内降解过程。自噬体的形成涉及动态的形态变化;盘状膜池生长，弯曲成杯状结构，最后发展成球形自噬体。我们已经构建了一个理论模型，集成了膜的形态变化和熵分区的假定曲率发生器，我们已经用来调查自噬体的形成过程定量。我们发现，膜曲率和分布的曲率发生器稳定的磁盘和杯形的中间结构在自噬体的形成，这是定量一致的体内观察。这些结果表明，各种自噬蛋白与膜曲率传感性能控制形态变化，通过稳定这些中间结构。我们的模型为理解自噬体的形成提供了一个框架。
英文摘要：
Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped structure, and finally develops into a spherical autophagosome. We have constructed a theoretical model that integrates the membrane morphological change and entropic partitioning of putative curvature generators, which we have used to investigate the autophagosome formation process quantitatively. We show that the membrane curvature and the distribution of the curvature generators stabilize disk- and cup-shaped intermediate structures during autophagosome formation, which is quantitatively consistent with in vivo observations. These results suggest that various autophagy proteins with membrane curvature-sensing properties control morphological change by stabilizing these intermediate structures. Our model provides a framework for understanding autophagosome formation.
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