细菌中偏好非AUG起始密码子的基因
Genes Preferring Non-AUG Start Codons in Bacteria
摘要：
在这里，我们研究翻译调控细菌通过分析在完全组装的基因组中的起始密码子的分布。我们报道了36个基因（infC，rpoC，rnpA等）。在进化上不同的门中显示出对非AUG起始密码子的偏好（“非AUG基因”）。大多数非AUG基因在功能上与翻译、转录或复制相关。在大肠在大肠杆菌中，必需基因所占的比例明显高于所有基因。此外，这些基因的功能分布表明，非AUG起始密码子可用于减少饥饿条件下的基因表达，可能通过翻译自身调节或IF3介导的调节。
英文摘要：
Here we investigate translational regulation in bacteria by analyzing the distribution of start codons in fully assembled genomes. We report 36 genes (infC, rpoC, rnpA, etc.) showing a preference for non-AUG start codons in evolutionarily diverse phyla ("non-AUG genes"). Most of the non-AUG genes are functionally associated with translation, transcription or replication. In E. coli, the percentage of essential genes among these 36 is significantly higher than among all genes. Furthermore, the functional distribution of these genes suggests that non-AUG start codons may be used to reduce gene expression during starvation conditions, possibly through translational autoregulation or IF3-mediated regulation.
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