波形蛋白细胞骨架：当聚合物物理学遇到细胞生物学
The vimentin cytoskeleton: When polymer physics meets cell biology
摘要：
组织的正常功能取决于细胞承受压力和保持形状的能力。这个过程的中心是细胞骨架，由三个聚合物网络组成：F-肌动蛋白，微管和中间丝。中间丝蛋白是细胞中最丰富的细胞骨架蛋白之一，但它们仍然是最不了解的蛋白之一。它们的结构和功能偏离它们的细胞骨架伙伴，F-肌动蛋白和微管。中间细丝网络显示出可延展性、柔性和韧性的独特组合，赋予细胞机械弹性。波形蛋白是间充质细胞中表达的中间丝蛋白。这篇综述强调了波形蛋白中间丝的物理生物学及其在整个细胞和组织应对压力中的作用的令人兴奋的新结果。
英文摘要：
The proper functions of tissues depend on the ability of cells to withstand stress and maintain shape. Central to this process is the cytoskeleton, comprised of three polymeric networks: F-actin, microtubules, and intermediate filaments. Intermediate filament proteins are among the most abundant cytoskeletal proteins in cells; yet they remain one of the least understood. Their structure and function deviate from those of their cytoskeletal partners, F-actin and microtubules. Intermediate filament networks show a unique combination of extensibility, flexibility and toughness that confers mechanical resilience to the cell. Vimentin is an intermediate filament protein expressed in mesenchymal cells. This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
