arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2008.06332eess.IVcs.CVcs.LGq-bio.QMstat.ML

Integrating uncertainty in deep neural networks for MRI based stroke analysis

University of Zurich (UZH)(苏黎世大学);Zurich University of Applied Sciences (ZHAW)(苏黎世应用科技大学);Konstanz University of Applied Sciences(康斯坦茨应用科技大学);University Hospital Zurich (UHZ)(苏黎世大学医院)

Lisa Herzog, Elvis Murina, Oliver Dürr, Susanne Wegener, Beate Sick

英文摘要:

At present, the majority of the proposed Deep Learning (DL) methods provide point predictions without quantifying the models uncertainty. However, a quantification of the reliability of automated image analysis is essential, in particular in medicine when physicians rely on the results for making critical treatment decisions. In this work, we provide an entire framework to diagnose ischemic stroke patients incorporating Bayesian uncertainty into the analysis procedure. We present a Bayesian Convolutional Neural Network (CNN) yielding a probability for a stroke lesion on 2D Magnetic Resonance (MR) images with corresponding uncertainty information about the reliability of the prediction. For patient-level diagnoses, different aggregation methods are proposed and evaluated, which combine the single image-level predictions. Those methods take advantage of the uncertainty in image predictions and report model uncertainty at the patient-level. In a cohort of 511 patients, our Bayesian CNN achieved an accuracy of 95.33% at the image-level representing a significant improvement of 2% over a non-Bayesian counterpart. The best patient aggregation method yielded 95.89% of accuracy. Integrating uncertainty information about image predictions in aggregation models resulted in higher uncertainty measures to false patient classifications, which enabled to filter critical patient diagnoses that are supposed to be closer examined by a medical doctor. We therefore recommend using Bayesian approaches not only for improved image-level prediction and uncertainty estimation but also for the detection of uncertain aggregations at the patient-level.

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