杆状细菌微菌落早期形态发生的非对称纯力学模型
A purely mechanical model with asymmetric features for early morphogenesis of rod-shaped bacteria micro-colony
摘要：
为了模拟杆状细菌微菌落的形态发生，在生物物理文献中已经提出了几种基于个体的模型。在研究微菌落形态时，大多数模型都考虑了相互作用力，如吸引力或子链力。在这篇文章中，我们提出了一个模型，其中细菌只通过非重叠约束进行交互。我们考虑了细菌的不对称性，以及它对与基底的摩擦的影响。此外，我们考虑了细菌沿其长度的质量分布的不对称性。这两个新的建模假设使我们能够检索微菌落生长的机械行为，而不需要相互作用，如吸引力。我们将我们的模型与不同的实验集进行比较，讨论我们的结果，并提出了几个量化器来系统地比较模型和数据。
英文摘要：
To model the morphogenesis of rod-shaped bacterial micro-colony, several individual-based models have been proposed in the biophysical literature. When studying the shape of micro-colonies, most models present interaction forces such as attraction or filial link. In this article, we propose a model where the bacteria interact only through non-overlapping constraints. We consider the asymmetry of the bacteria, and its influence on the friction with the substrate. Besides, we consider asymmetry in the mass distribution of the bacteria along their length. These two new modelling assumptions allow us to retrieve mechanical behaviours of micro-colony growth without the need of interaction such as attraction. We compare our model to various sets of experiments, discuss our results, and propose several quantifiers to compare model to data in a systematic way.
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