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arXiv 2008.04435q-bio.NC
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潜在的动力学变量在大型生物系统中产生时空临界性的特征

Latent dynamical variables produce signatures of spatiotemporal criticality in large biological systems

Mia C. Morrell, Audrey J. Sederberg, Ilya Nemenman

摘要:

由于可能的细胞-细胞相互作用的组合复杂性,理解大量神经元的活动是困难的。为了降低复杂性,粗粒化先前已被应用于实验神经记录,其显示了超过二十年的自由能,活动方差,特征值谱和相关时间的缩放,暗示小鼠海马在临界状态下运行。我们通过模拟耦合到少量长时间尺度随机场的条件独立二进制神经元来模拟实验,然后复制粗粒化过程和分析。这再现了实验观察到的缩放,表明它们可能是由神经元群体活动与潜在的动态刺激耦合而产生的。此外,我们模型的参数扫描表明,缩放的出现需要群体中的大多数细胞与潜在刺激耦合,预测即使是著名的位置细胞也必须对非位置刺激做出反应。

英文摘要:

Understanding the activity of large populations of neurons is difficult due to the combinatorial complexity of possible cell-cell interactions. To reduce the complexity, coarse-graining had been previously applied to experimental neural recordings, which showed over two decades of scaling in free energy, activity variance, eigenvalue spectra, and correlation time, hinting that the mouse hippocampus operates in a critical regime. We model the experiment by simulating conditionally independent binary neurons coupled to a small number of long-timescale stochastic fields and then replicating the coarse-graining procedure and analysis. This reproduces the experimentally-observed scalings, suggesting that they may arise from coupling the neural population activity to latent dynamic stimuli. Further, parameter sweeps for our model suggest that emergence of scaling requires most of the cells in a population to couple to the latent stimuli, predicting that even the celebrated place cells must also respond to non-place stimuli.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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