细菌群体感应中公共物品介导的种间演化动力学
Interspecies evolutionary dynamics mediated by public goods in bacterial quorum sensing
摘要：
细菌群体感应是细菌之间发生的通信，因为它们将某些分子分泌到细胞间介质中，这些分子随后被分泌细胞本身和其他细胞吸收。根据细胞密度，这种吸收有可能改变基因表达，从而影响群落的整体特性。我们考虑多个细菌物种共存的情况，将它们中的每一个称为基因型，并采用它们共同分泌的分子的通常命名为公共产品。在这种情况下的一个关键问题是表征基因型的共同进化，因为其中一些基因型分泌公共产品（并支付相关的代谢成本），而其他基因型则没有，但可能仍然受益于可用的公共产品。我们引入了一个网络模型来描述基因型的相互作用和进化时，基因型的健身依赖于生产和摄取的公共物品。该模型包括一个随机图，以总结可能的进化途径的基因型可能采取的，因为它们相互作用的遗传，和一个系统的耦合微分方程，以表征基因型丰度在时间上的行为。我们研究了一些简单的变化模型分析和更复杂的变化计算。我们的研究结果指出，一个简单的权衡影响那些基因型的长期生存，不生产公共产品。在生产者一方，这种权衡涉及生产和吸收公益的影响。在非生产者方面，它也涉及吸收公共产品的影响，现在生产者和非生产者之间的分子相容性使其更加复杂。根据这些因素的结果，生产者可能会生存，也可能不会生存。
英文摘要：
Bacterial quorum sensing is the communication that takes place between bacteria as they secrete certain molecules into the intercellular medium that later get absorbed by the secreting cells themselves and by others. Depending on cell density, this uptake has the potential to alter gene expression and thereby affect global properties of the community. We consider the case of multiple bacterial species coexisting, referring to each one of them as a genotype and adopting the usual denomination of the molecules they collectively secrete as public goods. A crucial problem in this setting is characterizing the coevolution of genotypes as some of them secrete public goods (and pay the associated metabolic costs) while others do not but may nevertheless benefit from the available public goods. We introduce a network model to describe genotype interaction and evolution when genotype fitness depends on the production and uptake of public goods. The model comprises a random graph to summarize the possible evolutionary pathways the genotypes may take as they interact genetically with one another, and a system of coupled differential equations to characterize the behavior of genotype abundance in time. We study some simple variations of the model analytically and more complex variations computationally. Our results point to a simple trade-off affecting the long-term survival of those genotypes that do produce public goods. This trade-off involves, on the producer side, the impact of producing and that of absorbing the public good. On the non-producer side, it involves the impact of absorbing the public good as well, now compounded by the molecular compatibility between the producer and the non-producer. Depending on how these factors turn out, producers may or may not survive.
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