Recursive linear structural equation models are widely used to postulate causal mechanisms underlying observational data. In these models, each variable equals a linear combination of a subset of the remaining variables plus an error term. When there is no unobserved confounding or selection bias, the error terms are assumed to be independent. We consider estimating a total causal effect in this setting. The causal structure is assumed to be known only up to a maximally oriented partially directed acyclic graph (MPDAG), a general class of graphs that can represent a Markov equivalence class of directed acyclic graphs (DAGs) with added background knowledge. We propose a simple estimator based on recursive least squares, which can consistently estimate any identified total causal effect, under point or joint intervention. We show that this estimator is the most efficient among all regular estimators that are based on the sample covariance, which includes covariate adjustment and the estimators employed by the joint-IDA algorithm. Notably, our result holds without assuming Gaussian errors.
Measuring treatment effects in observational studies is challenging because of confounding bias. Confounding occurs when a variable affects both the treatment and the outcome. Traditional methods such as propensity score matching estimate treatment effects by conditioning on the confounders. Recent literature has presented new methods that use machine learning to predict the counterfactuals in observational studies which then allow for estimating treatment effects. These studies however, have been applied to real world data where the true treatment effects have not been known. This study aimed…
Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are defined as linear combinations of effects on the outcome scale. In some situations, alternative quantifications of treatment effects may be more appropriate. In progressive diseases, for example, one may want to estimate if a drug has cumulative effects resulting in increasing efficacy over time or whether it slows the time progression of disease. This paper …
Principal stratification is a causal framework to analyze randomized experiments with a post-treatment variable between the treatment and endpoint variables. Because the principal strata defined by the potential outcomes of the post-treatment variable are not observable, we generally cannot identify the causal effects within principal strata. Motivated by a real data set of phase III adjuvant colon clinical trials, we propose approaches to identifying and estimating the principal causal effects via multiple trials. For the identifiability, we remove the commonly-used exclusion restriction assu…
The difference-in-differences (DID) design is widely used in observational studies to estimate the causal effect of a treatment when repeated observations over time are available. Yet, almost all existing methods assume linearity in the potential outcome (parallel trends assumption) and target the additive effect. In social science research, however, many outcomes of interest are measured on an ordinal scale. This makes the linearity assumption inappropriate because the difference between two ordinal potential outcomes is not well defined. In this paper, I propose a method to draw causal infer…
This paper presents a simple method for carrying out inference in a wide variety of possibly nonlinear IV models under weak assumptions. The method is non-asymptotic in the sense that it provides a finite sample bound on the difference between the true and nominal probabilities of rejecting a correct null hypothesis. The method is a non-Studentized version of the Anderson-Rubin test but is motivated and analyzed differently. In contrast to the conventional Anderson-Rubin test, the method proposed here does not require restrictive distributional assumptions, linearity of the estimated model, or…
We study a high-dimensional regression setting under the assumption of known covariate distribution. We aim at estimating the amount of explained variation in the response by the best linear function of the covariates (the signal level). In our setting, neither sparsity of the coefficient vector, nor normality of the covariates or linearity of the conditional expectation are assumed. We present an unbiased and consistent estimator and then improve it by using a zero-estimator approach, where a zero-estimator is a statistic whose expected value is zero. More generally, we present an algorithm b…
Johns Hopkins University（约翰斯·霍普金斯大学）；University of Pennsylvania（宾夕法尼亚大学）
Robins et al. (2008) introduced a class of influence functions (IFs) which could be used to obtain doubly robust moment functions for the corresponding parameters. However, that class does not include the IF of parameters for which the nuisance functions are solutions to integral equations. Such parameters are particularly important in the field of causal inference, specifically in the recently proposed proximal causal inference framework of Tchetgen Tchetgen et al. (2020), which allows for estimating the causal effect in the presence of latent confounders. In this paper, we first extend the c…
There are many settings where researchers are interested in estimating average treatment effects and are willing to rely on the unconfoundedness assumption, which requires that the treatment assignment be as good as random conditional on pre-treatment variables. The unconfoundedness assumption is often more plausible if a large number of pre-treatment variables are included in the analysis, but this can worsen the performance of standard approaches to treatment effect estimation. In this paper, we develop a method for de-biasing penalized regression adjustments to allow sparse regression metho…
Graph-based causal discovery methods aim to capture conditional independencies consistent with the observed data and differentiate causal relationships from indirect or induced ones. Successful construction of graphical models of data depends on the assumption of causal sufficiency: that is, that all confounding variables are measured. When this assumption is not met, learned graphical structures may become arbitrarily incorrect and effects implied by such models may be wrongly attributed, carry the wrong magnitude, or mis-represent direction of correlation. Wide application of graphical model…
The synthetic control (SC) method is a popular approach for estimating treatment effects from observational panel data. It rests on a crucial assumption that we can write the treated unit as a linear combination of the untreated units. This linearity assumption, however, can be unlikely to hold in practice and, when violated, the resulting SC estimates are incorrect. In this paper we examine two questions: (1) How large can the misspecification error be? (2) How can we limit it? First, we provide theoretical bounds to quantify the misspecification error. The bounds are comforting: small misspe…
