基于本体的COVID-19表型注释和分析
Ontology-based annotation and analysis of COVID-19 phenotypes
摘要：
COVID-19疫情对全球不同地区的公共卫生造成了不可预测的破坏性灾难。常见的表型包括发热、咳嗽、呼吸急促和寒战。随着更多的病例研究，其他临床表型逐渐被认识到，例如嗅觉丧失和味觉丧失。与出院或治愈的患者相比，重症或死亡的患者往往有一种或多种合并症，如高血压、糖尿病和心血管疾病。在这项研究中，我们系统地收集和分析了70篇文章中的COVID-19相关临床表型。基于人类表型本体论（HPO），将常见的17种表型分为不同的组。基于HP分类，我们系统分析了患者中确定的3种神经表型（嗅觉丧失、味觉丧失和头痛）和4种腹部表型（恶心、呕吐、腹痛和腹泻），发现来自欧洲和美国的患者比来自亚洲的患者具有更高的神经表型和腹部表型。在COVID-19患者中共发现23种合并症。与没有这些合并症的患者相比，患有这些合并症（如糖尿病和肾衰竭）的患者结局更差。
英文摘要：
The epidemic of COVID-19 has caused an unpredictable and devastated disaster to the public health in different territories around the world. Common phenotypes include fever, cough, shortness of breath, and chills. With more cases investigated, other clinical phenotypes are gradually recognized, for example, loss of smell, and loss of tastes. Compared with discharged or cured patients, severe or died patients often have one or more comorbidities, such as hypertension, diabetes, and cardiovascular disease. In this study, we systematically collected and analyzed COVID-19-related clinical phenotypes from 70 articles. The commonly occurring 17 phenotypes were classified into different groups based on the Human Phenotype Ontology (HPO). Based on the HP classification, we systematically analyze three nervous phenotypes (loss of smell, loss of taste, and headache) and four abdominal phenotypes (nausea, vomiting, abdominal pain, and diarrhea) identified in patients, and found that patients from Europe and USA turned to have higher nervous phenotypes and abdominal phenotypes than patients from Asia. A total of 23 comorbidities were found to commonly exist among COVID-19 patients. Patients with these comorbidities such as diabetes and kidney failure had worse outcomes compared with those without these comorbidities.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
