组装具有聚集依赖性抗菌活性的片状等离子体纳米颗粒
Assembling patchy plasmonic nanoparticles with aggregation-dependent antibacterial activity
摘要：
我们实现了一种抗菌纳米材料的基础上的自限组装的片状等离子体胶体，通过吸附溶菌酶的金纳米粒子。在几百纳米内选择组件尺寸的可能性允许在从可见光到近红外的宽频率范围内调谐它们的光学响应。我们还证明了催化活性的聚集依赖性调制，这导致适当大小的组装体的抗菌性能的增强。这种纳米材料的结构，光学性质和生物活性的全面控制，为开发新型抗菌纳米酶铺平了道路，在治疗多重耐药细菌方面具有广阔的应用前景。
英文摘要：
We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.
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