微生物生物表面活性剂介导pH-stimulated相变合成多层囊泡聚电解质-表面活性剂复合物
Synthesis of multilamellar walls vesicles polyelectrolyte-surfactant complexes from pH-stimulated phase transition using microbial biosurfactants
摘要：
多层壁囊泡（MLWV）是一类有趣的聚电解质-表面活性剂复合物（PESC），具有从家庭护理到生物医学产品的广泛应用。如果MLWV通常通过聚电解质驱动的囊泡凝集在伪平衡条件下获得，则所得相通常是多于一种结构的混合物。在这项工作中，我们表明，MLWV可以大规模和再现性制备从最近开发的方法，涉及pH刺激的相变从一个复杂的凝聚相（Co）。我们采用生物基pH敏感性微生物糖脂生物表面活性剂的存在下，天然的，或合成的，多胺（壳聚糖，聚-L-赖氨酸，聚乙烯亚胺，聚烯丙胺）。原位小角X射线散射（SAXS）和低温透射电子显微镜（cryo-TEM）显示了一个系统的同构和isodimensional过渡从Co的MLWV相，而光学显微镜下的偏振光实验和低温TEM揭示了大量的，几乎定量的MLWV的存在。最后，多层壁结构不受过滤和超声处理的干扰，这两种典型的方法用于控制囊泡中的尺寸分布。总之，这项工作突出了一种新的，强大的，非平衡相变方法来开发生物基多层壁囊泡，有前途的软胶体在个人护理，化妆品和制药等领域的应用。
英文摘要：
Multilamellar wall vesicles (MLWV) are an interesting class of polyelectrolyte-surfactant complexes (PESCs) for wide applications ranging from house-care to biomedical products. If MLWV are generally obtained by a polyelectrolyte-driven vesicle agglutination under pseudo-equilibrium conditions, the resulting phase is often a mixture of more than one structure. In this work, we show that MLWV can be massively and reproductively prepared from a recently developed method involving a pH-stimulated phase transition from a complex coacervate phase (Co). We employ a biobased pH-sensitive microbial glucolipid biosurfactant in the presence of a natural, or synthetic, polyamine (chitosan, poly-L-Lysine, polyethylene imine, polyallylamine). In situ small angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM) show a systematic isostructural and isodimensional transition from the Co to the MLWV phase, while optical microscopy under polarized light experiments and cryo-TEM reveal a massive, virtually quantitative, presence of MLWV. Finally, the multilamellar wall structure is not perturbed by filtration and sonication, two typical methods employed to control size distribution in vesicles. In summary, this work highlights a new, robust, non-equilibrium phase-change method to develop biobased multilamellar wall vesicles, promising soft colloids with applications in the field of personal care, cosmetics and pharmaceutics among many others.
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