使用强化学习为自我监测的I型糖尿病患者提供常见的推注顾问
Challenging common bolus advisor for self-monitoring type-I diabetes patients using Reinforcement Learning
摘要:
自我监测的糖尿病患者必须在每餐前决定他们应该服用多少胰岛素。存在标准的推注顾问,但从未被证明在任何意义上是最佳的。我们对这一规则提出了挑战,将强化学习技术应用于T1 DM模拟的数据,T1 DM是由Kovatchev等人开发的FDA批准的模拟器,用于模拟葡萄糖-胰岛素相互作用。结果表明,最佳大剂量规则与标准大剂量顾问有很大不同,如果遵循,实际上可以避免低血糖发作。
英文摘要:
Patients with diabetes who are self-monitoring have to decide right before each meal how much insulin they should take. A standard bolus advisor exists, but has never actually been proven to be optimal in any sense. We challenged this rule applying Reinforcement Learning techniques on data simulated with T1DM, an FDA-approved simulator developed by Kovatchev et al. modeling the gluco-insulin interaction. Results show that the optimal bolus rule is fairly different from the standard bolus advisor, and if followed can actually avoid hypoglycemia episodes.
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