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arXiv 2007.11641cs.CVcs.LGeess.IV
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基于注意力的多示例学习在血细胞疾病分类中的应用

Attention based Multiple Instance Learning for Classification of Blood Cell Disorders

Institute of Computational Biology, Helmholtz Zentrum München - German Research Center for Environmental Health(亥姆霍兹慕尼黑中心-德国环境健康研究中心计算生物学研究所);Computer Aided Medical Procedures, Technical University of Munich(慕尼黑工业大学计算机辅助医疗程序研究所);Helmholtz AI, Helmholtz Center Munich(慕尼黑亥姆霍兹中心亥姆霍兹人工智能);Red Blood Cell Research Group, Institute of Veterinary Physiology, Vetsuisse Faculty and the Zurich Center for Integrative Human Physiology, University of Zurich(苏黎世大学兽医学院兽医生理学研究所红细胞研究组及苏黎世综合人类生理学中心);Computer Aided Medical Procedures, Johns Hopkins University(约翰斯·霍普金斯大学计算机辅助医疗程序研究所);Computer Vision Lab (CVL), ETH Zurich(苏黎世联邦理工学院计算机视觉实验室)

Ario Sadafi, Asya Makhro, Anna Bogdanova, Nassir Navab, Tingying Peng, Shadi Albarqouni, Carsten Marr

摘要:

红细胞是高度可变形的,并以各种形状存在。在血细胞疾病中,只有所有细胞的一个子集发生形态学改变并与诊断相关。然而,手动标记所有细胞是费力的、复杂的,并且引入了专家间的可变性。我们提出了一种基于注意力的多实例学习方法来对患有血细胞疾病的患者的血液样本进行分类。使用R-CNN架构检测细胞。通过为每个细胞提取的特征,多实例学习方法将患者样本分类为四种血细胞疾病中的一种。注意力机制提供了每个细胞对整体分类的贡献的度量,并显著提高了网络的分类准确性及其对医学专家的可解释性。

英文摘要:

Red blood cells are highly deformable and present in various shapes. In blood cell disorders, only a subset of all cells is morphologically altered and relevant for the diagnosis. However, manually labeling of all cells is laborious, complicated and introduces inter-expert variability. We propose an attention based multiple instance learning method to classify blood samples of patients suffering from blood cell disorders. Cells are detected using an R-CNN architecture. With the features extracted for each cell, a multiple instance learning method classifies patient samples into one out of four blood cell disorders. The attention mechanism provides a measure of the contribution of each cell to the overall classification and significantly improves the network's classification accuracy as well as its interpretability for the medical expert.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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