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arXiv 2007.07126cond-mat.softphysics.bio-ph
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细胞片发育过程中大弯曲变形的形态弹性

Morphoelasticity of Large Bending Deformations of Cell Sheets during Development

Pierre A. Haas, Raymond E. Goldstein

摘要:

形态发生过程中细胞片层的变形是由细胞分裂和细胞形状变化等发育过程驱动的。在形态弹性壳理论的发展中,这些过程表现为薄弹性壳的固有几何形状的变化。然而,形态发生往往涉及大的弯曲变形,这些壳理论的有效性的正式范围之外。在这里,通过渐近展开的三维不可压缩形态弹性极限的薄壳,我们推导出一个壳理论大的内在弯曲变形,并强调由此产生的几何材料的各向异性和弹性作用的细胞收缩。以内陷的绿色pendulum团藻作为一个模型的发展事件,我们展示了这个理论的结果是如何不同的经典壳理论,是不是正式有效的这些大的弯曲变形,并揭示了这些几何效应如何稳定内陷。

英文摘要:

Deformations of cell sheets during morphogenesis are driven by developmental processes such as cell division and cell shape changes. In morphoelastic shell theories of development, these processes appear as variations of the intrinsic geometry of a thin elastic shell. However, morphogenesis often involves large bending deformations that are outside the formal range of validity of these shell theories. Here, by asymptotic expansion of three-dimensional incompressible morphoelasticity in the limit of a thin shell, we derive a shell theory for large intrinsic bending deformations and emphasise the resulting geometric material anisotropy and the elastic role of cell constriction. Taking the invagination of the green alga Volvox as a model developmental event, we show how results for this theory differ from those for a classical shell theory that is not formally valid for these large bending deformations and reveal how these geometric effects stabilise invagination.

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