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arXiv 2007.06136stat.AP
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贝叶斯双聚类方法及其在计算生物学中的应用

Bayesian Bi-clustering Methods with Applications in Computational Biology

Han Yan, Jiexing Wu, Yang Li, Jun S. Liu

摘要:

双聚类是一种有用的方法,在分析生物数据时,观察来自异质群体,并有大量的功能。我们概述了一个一般的贝叶斯方法在处理双聚类问题,在中等到高的维度,并提出了三个贝叶斯双聚类模型的分类数据,增加了复杂性,在他们的建模跨双集群的特征分布。我们提出的方法适用于广泛的场景:从数据仅在一小部分特征中可区分但被大量噪声掩盖的情况,到不同组的数据由不同的特征集或数据呈现层次结构来识别的情况。通过模拟研究,我们表明,我们的方法优于现有的(双)聚类方法在识别集群和恢复跨双集群的特征分布模式。我们将我们的方法应用于两个遗传数据集,尽管我们的方法的应用领域更广。

英文摘要:

Bi-clustering is a useful approach in analyzing biological data when observations come from heterogeneous groups and have a large number of features. We outline a general Bayesian approach in tackling bi-clustering problems in moderate to high dimensions, and propose three Bayesian bi-clustering models on categorical data, which increase in complexities in their modeling of the distributions of features across bi-clusters. Our proposed methods apply to a wide range of scenarios: from situations where data are cluster-distinguishable only among a small subset of features but masked by a large amount of noise, to situations where different groups of data are identified by different sets of features or data exhibit hierarchical structures. Through simulation studies, we show that our methods outperform existing (bi-)clustering methods in both identifying clusters and recovering feature distributional patterns across bi-clusters. We apply our methods to two genetic datasets, though the area of application of our methods is even broader.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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