自适应眼镜无波前传感器全视场OCT,用于宽视场范围内的高分辨率视网膜成像
Adaptive-glasses wavefront sensorless full-field OCT for high-resolution retinal imaging over a wide field-of-view
摘要:
通过结合光学相干断层扫描(OCT)和自适应光学(AO),可以实现体内视网膜成像中可能的最高三维(3D)分辨率。然而,这种组合带来了重要的限制,例如小视场和复杂,笨重的系统,到目前为止,阻止了这项技术从研究实验室到诊所的转化。在这封信中,我们介绍了一种方法,避免了这些限制,使用多执行器自适应镜头就在眼前,在一种技术,我们称之为自适应眼镜波前传感器的方法。我们在紧凑型全视场OCT(FFOCT)视网膜成像仪上实现了这种方法,而不会增加其占地面积或光学复杂性。通过自适应眼镜方法校正眼像差增加了FFOCT信噪比,并使我们能够在5° $\times$ 5°视场中以3D细胞分辨率成像不同的视网膜层,而没有明显的非等晕现象。
英文摘要:
The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics (AO). However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. In this Letter, we introduce an approach that avoids these limitations by using a multi-actuator adaptive lens just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. We implemented this approach on our compact full-field OCT (FFOCT) retinal imager without increasing its footprint or optical complexity. The correction of ocular aberrations through the adaptive-glasses approach increased the FFOCT signal-to-noise ratio and enabled us to image different retinal layers with a 3D cellular resolution in a 5° $\times$ 5° field-of-view, without apparent anisoplanatism.
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