柔性脂质囊泡对微粒的包裹
Wrapping of Microparticles by Floppy Lipid Vesicles
摘要：
脂质膜是定义活细胞及其许多亚区室的屏障，与各种各样的纳米和微米尺寸的物体结合。在强粘附力的存在下，膜可以强烈变形并包裹颗粒，这是穿过膜进行各种健康和疾病相关过程的重要步骤。大量的理论和数值工作都集中在确定包裹的物理性质。使用的模型系统的微米级的胶体颗粒和巨大的单层脂质囊泡与可调的粘附力，我们测量的包裹相图，并进行定量比较的理论模型。我们的数据是一致的膜-颗粒相互作用占每单位面积的粘附能，膜的弯曲刚度，颗粒大小和囊泡半径的模型。
英文摘要：
Lipid membranes, the barrier defining living cells and many of their sub-compartments, bind to a wide variety of nano- and micro-meter sized objects. In the presence of strong adhesive forces, membranes can strongly deform and wrap the particles, an essential step in crossing the membrane for a variety of health and disease-related processes. A large body of theoretical and numerical work has focused on identifying the physical properties that underly wrapping. Using a model system of micron-sized colloidal particles and giant unilamellar lipid vesicles with tunable adhesive forces, we measure a wrapping phase diagram and make quantitative comparisons to theoretical models. Our data is consistent with a model of membrane-particle interactions accounting for the adhesive energy per unit area, membrane bending rigidity, particle size, and vesicle radius.
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