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arXiv 2007.00311cs.CV

Towards Explainable Graph Representations in Digital Pathology

EPFL(洛桑联邦理工学院);IBM Research Zürich(IBM苏黎世研究院);ETH Zürich(苏黎世联邦理工学院);National Cancer Institute - IRCCS-Fondazione Pascale(国家癌症研究所 - IRCCS帕斯卡尔基金会)

Guillaume Jaume, Pushpak Pati, Antonio Foncubierta-Rodriguez, Florinda Feroce, Giosue Scognamiglio, Anna Maria Anniciello, Jean-Philippe Thiran, Orcun Goksel, Maria Gabrani

英文摘要:

Explainability of machine learning (ML) techniques in digital pathology (DP) is of great significance to facilitate their wide adoption in clinics. Recently, graph techniques encoding relevant biological entities have been employed to represent and assess DP images. Such paradigm shift from pixel-wise to entity-wise analysis provides more control over concept representation. In this paper, we introduce a post-hoc explainer to derive compact per-instance explanations emphasizing diagnostically important entities in the graph. Although we focus our analyses to cells and cellular interactions in breast cancer subtyping, the proposed explainer is generic enough to be extended to other topological representations in DP. Qualitative and quantitative analyses demonstrate the efficacy of the explainer in generating comprehensive and compact explanations.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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