一种修正的Armitage检验,适用于比例的线性趋势以上
A modified Armitage test for more than a linear trend on proportions
摘要:
可以使用多重边际模型方法修改比例线性趋势的Armitage检验,用于同时具有算术、序数和对数剂量评分的三个回归模型,以有效应对广泛的可能剂量反应关系。此外,它可以用于特殊的设计,在广义线性(混合)模型的三个常见的效应大小比值比,风险比和风险差。相关的R软件包tukeytrend允许简单的概括,例如分析具有可能的平台形状的2 × k表格数据或分析过度分散的比例。在R软件包的一个小插图中可以获得对进一步实际数据示例的评估。
英文摘要:
The Armitage test for linear trend in proportions can be modified using the multiple marginal model approach for three regression models with arithmetic, ordinal and logarithmic dose scores simultaneously, to be powerful against a wide range of possible dose response relationships. Moreover, it can be used for particular designs in the generalized linear (mixed) model for the three common effect sizes odds ratio, risk ratio and risk difference. The related R package tukeytrend allows simple generalizations, e.g. the analysis 2-by-k table data with a possible plateau shape or analysing overdispersed proportions. The evaluation of further real data examples are available in a vignette to that R package.
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