纤维化对称性破坏的电路在生物网络中执行核心逻辑计算
Circuits with broken fibration symmetries perform core logic computations in biological networks
摘要：
我们表明，逻辑计算电路在基因调控网络中产生的纤维对称性破缺的网络结构。从这个想法中，我们实施了一个建设性的程序，揭示了遗传电路的层次结构，在物种中无处不在，这是令人惊讶的类似物的象征性电路的固态电子：从晶体管开始，发展到环形振荡器，电流镜电路，切换开关和触发器。这些规范变体服务于同步和时钟（在其对称状态下）和存储器存储（在其破缺对称状态下）的基本操作。这些结论为寻找生物网络中的计算构建模块提供了理论上的原则性策略，并为设计合成生物电路提供了系统的路线。
英文摘要：
We show that logic computational circuits in gene regulatory networks arise from a fibration symmetry breaking in the network structure. From this idea we implement a constructive procedure that reveals a hierarchy of genetic circuits, ubiquitous across species, that are surprising analogues to the emblematic circuits of solid-state electronics: starting from the transistor and progressing to ring oscillators, current-mirror circuits to toggle switches and flip-flops. These canonical variants serve fundamental operations of synchronization and clocks (in their symmetric states) and memory storage (in their broken symmetry states). These conclusions introduce a theoretically principled strategy to search for computational building blocks in biological networks, and present a systematic route to design synthetic biological circuits.
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