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arXiv 2006.07352q-bio.NCcs.AIcs.LGcs.SYeess.SY
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Deep Reinforcement Learning for Neural Control

University of Washington(华盛顿大学)

Jimin Kim, Eli Shlizerman

英文摘要:

We present a novel methodology for control of neural circuits based on deep reinforcement learning. Our approach achieves aimed behavior by generating external continuous stimulation of existing neural circuits (neuromodulation control) or modulations of neural circuits architecture (connectome control). Both forms of control are challenging due to nonlinear and recurrent complexity of neural activity. To infer candidate control policies, our approach maps neural circuits and their connectome into a grid-world like setting and infers the actions needed to achieve aimed behavior. The actions are inferred by adaptation of deep Q-learning methods known for their robust performance in navigating grid-worlds. We apply our approach to the model of \textit{C. elegans} which simulates the full somatic nervous system with muscles and body. Our framework successfully infers neuropeptidic currents and synaptic architectures for control of chemotaxis. Our findings are consistent with in vivo measurements and provide additional insights into neural control of chemotaxis. We further demonstrate the generality and scalability of our methods by inferring chemotactic neural circuits from scratch.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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