用于表面增强拉曼光谱的多层片状薄膜分散凝胶
Multilayer Thin-Film Flake Dispersion Gel for Surface-Enhanced Raman Spectroscopy
摘要：
银纳米棒阵列/银纳米棒/镜面结构的多层薄膜是众所周知的高灵敏度表面增强拉曼散射（SERS）基底，其通过光的干涉增强拉曼散射截面。然而，使用这些固体基质直接从人类皮肤提取生物标志物是困难的。为了克服这个问题，我们提出了一种多层薄膜薄片分散凝胶离心混合的多层薄膜和羟乙基纤维素（HEC）凝胶。采用动态倾斜角沉积技术，通过连续双沉积制备多层薄膜。对混合过程进行了优化，以获得约10 μm的薄片，从而可以保持多层膜的光学特性，并且不会对人体产生不良影响。用4，4 ′-联吡啶（BPY）测试了片状分散凝胶的表面增强拉曼光谱（SERS）特征。BPY分子在几秒钟内扩散通过高度多孔的凝胶，产生显著的SERS信号。多层膜薄片分散凝胶显示SERS信号比没有多层膜结构的凝胶分散的Ag纳米棒阵列好约20倍。这些SERS活性薄片分散凝胶可直接用于皮肤表面，从汗液中收集体液，用于生物标志物传感。
英文摘要：
Ag nanorod arrays/dielectrics/mirror-structured multilayer thin-film are well known, highly sensitive surface-enhanced Raman scattering (SERS) substrates that enhance the Raman scattering cross-section by the interference of light. However, extracting biomarkers directly from human skin using these solid substrates is difficult. To overcome this problem, we propose a multilayer thin-film flake dispersion gel by centrifugal mixing of the multilayer thin-film and hydroxyethyl cellulose (HEC) gel. The multilayer thin-film was prepared by serial bideposition using the dynamic oblique angle deposition technique. The mixing process was optimized to obtain flakes of ~10 μm so that the optical properties of the multilayer film can be preserved, and there is no risk of adverse effects on humans. The SERS features of the flakes dispersion gel were tested using 4, 4'-bipyridine (BPY). The BPY molecules diffused through the highly porous gel within a few seconds, generating significant SERS signals. The multilayer film flakes dispersion gel showed a SERS signal about 20 times better than the gel-dispersed Ag nanorod arrays without a multilayer film structure. These SERS active flakes dispersion gel can be used directly on the skin surface to collect body fluids from sweat, for biomarker sensing.
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