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arXiv 2005.13489q-bio.TOq-bio.PE
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红茶对无机砷致癌作用的免疫调节作用

Immunomodulatory role of black tea in the mitigation of cancer induced by inorganic arsenic

Ravi Kiran, Swati Tyagi, Syed Abbas, Madhumita Roy, A. Taraphder

摘要:

我们提出了一个模型分析肿瘤和正常细胞生长的影响下,致癌剂,免疫调节剂(IM)和可变流入的免疫细胞,包括相关的相互作用。肿瘤的生长是由致癌物质,如无机砷促进,而在这里考虑的IM是红茶(山茶)。观察到具有可变免疫细胞流入的模型相对于恒定流入模型具有相当大的优势,并且虽然肿瘤细胞群体大大减轻,但正常细胞群体保持高于健康水平。正常和肿瘤细胞的演化计算从所提出的模型和他们的局部稳定性进行了研究分析。进行数值模拟研究的长期动态和各种因素的影响进行了估计。这有助于开发一种平衡的肿瘤缓解策略,而不使用通常具有强烈副作用的化疗药物。

英文摘要:

We present a model analysis of the tumor and normal cell growth under the influence of a carcinogenic agent, an immunomdulator (IM) and variable influx of immune cells including relevant interactions. The tumor growth is facilitated by carcinogens such as inorganic arsenic while the IM considered here is black tea (Camellia sinesnsis). The model with variable influx of immune cells is observed to have considerable advantage over the constant influx model, and while the tumor cell population is greatly mitigated, normal cell population remains above healthy levels. The evolution of normal and tumor cells are computed from the proposed model and their local stabilities are investigated analytically. Numerical simulations are performed to study the long term dynamics and an estimation of the effects of various factors is made. This helps in developing a balanced strategy for tumor mitigation without the use of chemotherapeutic drugs that usually have strong side-effects.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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