具有上游运动能力的仿生声磁微群机器人
Bio-inspired acousto-magnetic microswarm robots with upstream motility
摘要：
逆水流推进的能力，即，进行积极的趋流性，可以为靶向治疗和非侵入性手术的应用提供令人兴奋的机会。迄今为止，当微粒处于背景流体流中时，不存在用于将微粒向上游导航的生物相容性技术。许多自然发生的microswimmer，如细菌，精子和浮游生物，利用壁的非滑动边界条件，表现出上游推进的启发，在这里，我们报告的设计和表征的自组装的微群，可以执行上游运动的外部声学和磁场的组合。声和磁场对人体都是安全的，非侵入性的，可以深入人体，并且在临床环境中得到了很好的发展。两种场的结合可以克服单一驱动方法遇到的限制。讨论了微群进行滚动运动所需的声致反作用力的设计准则。我们的实验数据和我们的模型，捕捉滚动行为之间的定量协议。上游能力提供了一种设计策略，用于将小药物分子递送到难以到达的部位，并代表了实现微系统和纳米系统逆血流导航的基本步骤。
英文摘要：
The ability to propel against flows, i.e., to perform positive rheotaxis, can provide exciting opportunities for applications in targeted therapeutics and non-invasive surgery. To date, no biocompatible technologies exist for navigating microparticles upstream when they are in a background fluid flow. Inspired by many naturally occurring microswimmers such as bacteria, spermatozoa, and plankton that utilize the non-slip boundary conditions of the wall to exhibit upstream propulsion, here, we report on the design and characterization of self-assembled microswarms that can execute upstream motility in a combination of external acoustic and magnetic fields. Both acoustic and magnetic fields are safe to humans, non-invasive, can penetrate deeply into the human body, and are well-developed in clinical settings. The combination of both fields can overcome the limitations encountered by single actuation methods. The design criteria of the acoustically-induced reaction force of the microswarms, which is needed to perform rolling-type motion, are discussed. We show quantitative agreement between experimental data and our model that captures the rolling behaviour. The upstream capability provides a design strategy for delivering small drug molecules to hard-to-reach sites and represents a fundamental step toward the realization of micro- and nanosystem-navigation against the blood flow.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
