TKF91模型下序列长度一致距离估计的不可能性
Impossibility of consistent distance estimation from sequence lengths under the TKF91 model
摘要:
我们考虑的问题下的TKF 91模型的序列进化的插入,删除和取代的同源性的距离估计。在一个渐近制度,预期的序列长度趋于无穷大,我们表明,没有一致的距离估计是可能的序列长度。更正式地说,我们建立的分布对序列长度在不同的距离不能区分概率去1。
英文摘要:
We consider the problem of distance estimation under the TKF91 model of sequence evolution by insertions, deletions and substitutions on a phylogeny. In an asymptotic regime where the expected sequence lengths tend to infinity, we show that no consistent distance estimation is possible from sequence lengths alone. More formally, we establish that the distributions of pairs of sequence lengths at different distances cannot be distinguished with probability going to one.
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