基于Tractometry的单受试者脑白质异常检测
Tractometry-based Anomaly Detection for Single-subject White Matter Analysis
摘要:
迫切需要从组间比较到弥散MRI(dMRI)个体诊断的范式转变,以分析罕见病例和临床异质性组。深度自动编码器在检测神经成像数据中的异常方面显示出巨大的潜力。我们提出了一个框架,操作上的白质(WM)途径的多种学习规范的微观结构特征,并区分那些在儿科人群中的控制遗传风险。
英文摘要:
There is an urgent need for a paradigm shift from group-wise comparisons to individual diagnosis in diffusion MRI (dMRI) to enable the analysis of rare cases and clinically-heterogeneous groups. Deep autoencoders have shown great potential to detect anomalies in neuroimaging data. We present a framework that operates on the manifold of white matter (WM) pathways to learn normative microstructural features, and discriminate those at genetic risk from controls in a paediatric population.
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