能量消耗对T细胞识别外源和自身的准确性、敏感性、特异性、速度和适应性的影响
The Role of Energy Cost on Accuracy, Sensitivity, Specificity, Speed and Adaptation of T Cell Foreign and Self Recognition
摘要：
已经以各种方式研究了包括T细胞辨别过程的生物系统中能量消耗的关键作用。T细胞识别中的动力学校正（KPR）涉及不同水平的能量耗散，影响功能结果，如错误率和特异性。在这项工作中，我们定量研究了能源成本如何影响错误分数，灵敏度，特异性，平均首次通过时间（MFPT）和适应错误的动力学速度。这些为充分理解T细胞动力学提供了背景。结果发现，能量在系统中起着核心作用，其目的是实现最小的误差分数和最大的灵敏度和特异性，以最快的速度在我们的动力学方案，动力学参数的数值是专门选择的，但这样的条件可以打破与不同的数据。从应用稳态近似（SSA）与KPR，这是用来量化各种可观的每个复杂的产生的浓度的评估，我们提出了详细的分析和数值结果。
英文摘要：
The critical role of energy consumption in biological systems including T cell discrimination process has been investigated in various ways. The kinetic proofreading(KPR) in T cell recognition involving different levels of energy dissipation influences functional outcomes such as error rates and specificity. In this work, we study quantitatively how the energy cost influences error fractions, sensitivity, specificity, kinetic speed in terms of Mean First Passage Time(MFPT) and adaption errors. These provide the background to adequately understand T cell dynamics. It is found that energy plays a central role in the system that aims to achieve minimum error fractions and maximum sensitivity and specificity with the fastest speed under our kinetic scheme for which numerical values of kinetic parameters are specially chosen, but such a condition can be broken with varying data. Starting with the application of steady state approximation(SSA) to the evaluation of the concentration of each complex produced associated with KPR, which is used to quantify various observables, we present both analytical and numerical results in detail.
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