arXivDaily arXiv每日学术速递 周一至周五更新
北美退伍军人节(Veterans Day),12 日无更新
arXiv 2005.01313nlin.PSphysics.bio-ph
收藏

恶性肿瘤侵袭的尖锋移动边界模型

A sharp-front moving boundary model for malignant invasion

Maud El-Hachem, Scott W McCue, Matthew J Simpson

摘要:

我们分析了一种新的数学模型的恶性肿瘤的侵袭,它采取的形式是一个两相移动边界问题描述的人口的恶性肿瘤细胞的背景组织,如皮肤的人口的入侵。两个群体中的细胞经历扩散迁移和逻辑增殖。两个种群之间的界面根据两相Stefan条件移动。与许多恶性肿瘤侵袭的反应扩散模型不同,移动边界模型明确地描述了癌症和周围组织之间的尖锐前沿的运动,而不需要引入退化的非线性扩散。数值模拟表明,该模型产生了非常有趣的行波解,以速度$c$移动,该模型支持恶性入侵和恶性撤退,其中行波可以在正或负$x$方向移动。与其中行波以最小波速$c \ge c^* > 0$移动的充分研究的Fisher-Kolmogorov和Porous-Fisher模型不同,移动边界模型导致具有$|c| < c^{**}$的行波解。我们解释这些行波解的相平面,并表明,它们与经典的费舍尔-Kolmogorov相平面的几个功能,往往被忽视的非物理。我们表明,数值计算,相平面分析比较以及与长时间的解决方案,从全偏微分方程模型,以及提供准确的扰动近似的行波的形状。

英文摘要:

We analyse a novel mathematical model of malignant invasion which takes the form of a two-phase moving boundary problem describing the invasion of a population of malignant cells into a population of background tissue, such as skin. Cells in both populations undergo diffusive migration and logistic proliferation. The interface between the two populations moves according to a two-phase Stefan condition. Unlike many reaction-diffusion models of malignant invasion, the moving boundary model explicitly describes the motion of the sharp front between the cancer and surrounding tissues without needing to introduce degenerate nonlinear diffusion. Numerical simulations suggest the model gives rise to very interesting travelling wave solutions that move with speed $c$, and the model supports both malignant invasion and malignant retreat, where the travelling wave can move in either the positive or negative $x$-directions. Unlike the well-studied Fisher-Kolmogorov and Porous-Fisher models where travelling waves move with a minimum wave speed $c \ge c^* > 0$, the moving boundary model leads to travelling wave solutions with $|c| < c^{**}$. We interpret these travelling wave solutions in the phase plane and show that they are associated with several features of the classical Fisher-Kolmogorov phase plane that are often disregarded as being nonphysical. We show, numerically, that the phase plane analysis compares well with long time solutions from the full partial differential equation model as well as providing accurate perturbation approximations for the shape of the travelling waves.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑