arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2005.00840cs.LGcs.AI

Decision Support for Intoxication Prediction Using Graph Convolutional Networks

Technische Universität München(慕尼黑工业大学);Johns Hopkins University(约翰斯·霍普金斯大学);Ludwig-Maximilians Universität München(慕尼黑大学)

Hendrik Burwinkel, Matthias Keicher, David Bani-Harouni, Tobias Zellner, Florian Eyer, Nassir Navab, Seyed-Ahmad Ahmadi

英文摘要:

Every day, poison control centers (PCC) are called for immediate classification and treatment recommendations if an acute intoxication is suspected. Due to the time-sensitive nature of these cases, doctors are required to propose a correct diagnosis and intervention within a minimal time frame. Usually the toxin is known and recommendations can be made accordingly. However, in challenging cases only symptoms are mentioned and doctors have to rely on their clinical experience. Medical experts and our analyses of a regional dataset of intoxication records provide evidence that this is challenging, since occurring symptoms may not always match the textbook description due to regional distinctions, inter-rater variance, and institutional workflow. Computer-aided diagnosis (CADx) can provide decision support, but approaches so far do not consider additional information of the reported cases like age or gender, despite their potential value towards a correct diagnosis. In this work, we propose a new machine learning based CADx method which fuses symptoms and meta information of the patients using graph convolutional networks. We further propose a novel symptom matching method that allows the effective incorporation of prior knowledge into the learning process and evidently stabilizes the poison prediction. We validate our method against 10 medical doctors with different experience diagnosing intoxication cases for 10 different toxins from the PCC in Munich and show our method's superiority in performance for poison prediction.

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