arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2004.10231stat.MEstat.AP
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基于特征向量的稀疏典型相关分析:多典型向量估计的快速计算

Eigenvector-based sparse canonical correlation analysis: Fast computation for estimation of multiple canonical vectors

Wenjia Wang, Yi-Hui Zhou

摘要:

经典的典型相关分析(CCA)要求矩阵是低维的,即特征的数量不能超过样本量。CCA的最新发展主要集中在高维设置,其中分析的两个矩阵中的特征数量大大超过了样本量。这些方法在需要迭代求解的优化问题中施加惩罚,并顺序地估计多个典型向量。在这项工作中,我们提供了稀疏多元回归与稀疏典型相关分析之间的明确联系,以及一种有效的算法,可以同时估计多个典型对,而不是顺序。此外,该算法自然允许并行计算。这些性质使得算法更加有效。我们提供了理论结果的一致性的典范对。该算法和理论的发展是基于解决的特征向量问题,显着区分我们的方法与现有的方法。仿真结果支持所提出的方法的改进性能。我们应用基于特征向量的CCA分析GTEx甲状腺组织学图像,分析SNP和RNA-seq基因表达数据以及微生物组研究。实际数据分析也表明,改进的性能相比,传统的稀疏CCA。

英文摘要:

Classical canonical correlation analysis (CCA) requires matrices to be low dimensional, i.e. the number of features cannot exceed the sample size. Recent developments in CCA have mainly focused on the high-dimensional setting, where the number of features in both matrices under analysis greatly exceeds the sample size. These approaches impose penalties in the optimization problems that are needed to be solve iteratively, and estimate multiple canonical vectors sequentially. In this work, we provide an explicit link between sparse multiple regression with sparse canonical correlation analysis, and an efficient algorithm that can estimate multiple canonical pairs simultaneously rather than sequentially. Furthermore, the algorithm naturally allows parallel computing. These properties make the algorithm much efficient. We provide theoretical results on the consistency of canonical pairs. The algorithm and theoretical development are based on solving an eigenvectors problem, which significantly differentiate our method with existing methods. Simulation results support the improved performance of the proposed approach. We apply eigenvector-based CCA to analysis of the GTEx thyroid histology images, analysis of SNPs and RNA-seq gene expression data, and a microbiome study. The real data analysis also shows improved performance compared to traditional sparse CCA.

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