NMR兼容的微流体平台实现原位电化学
An NMR-compatible microfluidic platform enabling in situ electrochemistry
摘要：
将微流体装置与核磁共振（NMR）相结合，有可能释放其巨大的样品处理和处理操作空间，以与NMR提供的强大分析一起使用。从NMR的角度来看，一类特别具有挑战性的集成功能元件是导电结构。金属电极可用于例如电化学样品相互作用，但它们可导致严重的NMR光谱退化。在这项研究中，模拟和实验验证的组合被用来确定一个电极的几何形状，在NMR光谱参数方面，以及没有电极的情况下，执行。通过将金属轨道放置在微流体通道的侧壁中，我们发现NMR RF激发性能实际上得到增强，而不损害$B_0$均匀性。监测原位沉积的壳聚糖在微流控平台中提出的电化学过程的NMR表征的概念验证演示。
英文摘要：
Combining microfluidic devices with nuclear magnetic resonance (NMR) has the potential of unlocking their vast sample handling and processing operation space for use with the powerful analytics provided by NMR. One particularly challenging class of integrated functional elements from the perspective of NMR are conductive structures. Metallic electrodes could be used for electrochemical sample interaction for example, yet they can cause severe NMR spectral degradation. In this study, a combination of simulation and experimental validation was used to identify an electrode geometry that, in terms of NMR spectral parameters, performs as well as for the case when no electrodes are present. By placing the metal tracks in the side-walls of a microfluidic channel, we found that NMR RF excitation performance was actually enhanced, without compromising $B_0$ homogeneity. Monitoring in situ deposition of chitosan in the microfluidic platform is presented as a proof-of-concept demonstration of NMR characterisation of an electrochemical process.
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