额顶连接神经反馈训练对健康男性工作记忆的促进作用：一项fNIRS研究
Frontoparietal Connectivity Neurofeedback Training for Promotion of Working Memory: An fNIRS Study in Healthy Male Participants
摘要：
神经反馈认知训练是一种有效促进认知功能的工具。在这项研究中，我们调查了一种新的功能近红外光谱（fNIRS）的额顶叶功能连接（FC）的神经反馈训练范式相关的工作记忆，涉及健康成年人。与传统的认知训练研究相比，我们选择了额顶叶网络作为神经反馈，这是认知功能调节的关键脑区，产生了很强的靶向效应。在实验中，10名被试（实验组）接受了3次为期15 min的认知训练，使用基于fNIRS的额顶FC作为神经反馈，另10名被试作为对照组。与对照组相比，试验组的额顶FC显著增加（p D 0.03），认知功能（记忆和注意力）显著提高（3-back测试准确性：p D 0.0005，3-back测试反应时：p D 0.0009）。在对长期训练效果和不同患者人群进行额外验证后，所提出的方法显示出相当大的潜力，可开发为一种快速，有效和广泛的认知功能增强训练方法。
英文摘要：
Neurofeedback cognitive training is a promising tool used to promote cognitive functions effectively and efficiently. In this study, we investigated a novel functional near-infrared spectroscopy (fNIRS)-based frontoparietal functional connectivity (FC) neurofeedback training paradigm related to working memory, involving healthy adults. Compared with conventional cognitive training studies, we chose the frontoparietal network, a key brain region for cognitive function modulation, as neurofeedback, yielding a strong targeting effect. In the experiment, 10 participants (test group) received three cognitive training sessions of 15 min using fNIRS-based frontoparietal FC as neurofeedback, and another 10 participants served as the control group. Frontoparietal FC was significantly increased in the test group (p D 0.03), and the cognitive functions (memory and attention) were significantly promoted compared with the control group (accuracy of 3-back test: p D 0.0005, reaction time of 3-back test: p D 0.0009). After additional validations on long-term training effect and on different patient populations, the proposed method exhibited considerable potential to be developed as a fast, effective, and widespread training approach for cognitive function enhancement.
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