tACS通过增强稳态视觉诱发电位促进闪烁驾驶
tACS Facilitates Flickering Driving by Boosting Steady-State Visual Evoked Potentials
摘要：
经颅交流电刺激（transcranial alternating current stimulation，tACS）在近十年前问世以来，受到越来越多的关注。tACS在调节大脑状态中是一个活跃研究领域，并已被证明在各种神经心理学和临床领域有效。在视觉领域中，许多努力致力于脑节律和节律刺激，即，tACS。然而，很少有人知道的节奏刺激和视觉刺激之间的相互作用。在这里，我们使用稳态视觉诱发电位（SSVEP），诱导闪烁驱动作为一种广泛使用的技术，频率标记，调查的后效tACS在健康人受试者。在20分钟10 Hz tACS给药前后记录了7块64通道脑电图，同时受试者执行了几个SSVEP任务。我们通过比较和验证真实tACS和假tACS中块之间和块内的时间、空间、时空和信噪比（SNR）模式来表征tACS后效的生理特性。我们的结果显示，tACS提高10-Hz SSVEP显着。此外，SSVEP的后效随着时间的推移而减轻，并持续了5分钟。我们的研究结果表明，通过外部节律刺激促进闪烁驱动的可行性，并打开了一个新的可能性，通过非侵入性经颅脑刺激改变大脑状态的方向。
英文摘要：
There has become of increasing interest in transcranial alternating current stimulation (tACS) since its inception nearly a decade ago. tACS in modulating brain state is an active area of research and has been demonstrated effective in various neuropsychological and clinical domains. In the visual domain, much effort has been dedicated to brain rhythms and rhythmic stimulation, i.e., tACS. However, little is known about the interplay between the rhythmic stimulation and visual stimulation. Here, we used steady-state visual evoked potential (SSVEP), induced by flickering driving as a widely used technique for frequency-tagging, to investigate the aftereffect of tACS in healthy human subjects. Seven blocks of 64-channel electroencephalogram were recorded before and after the administration of 20-min 10-Hz tACS, while subjects performed several blocks of SSVEP tasks. We characterized the physiological properties of tACS aftereffect by comparing and validating the temporal, spatial, spatiotemporal and signal-to-noise ratio (SNR) patterns between and within blocks in real tACS and sham tACS. Our result revealed that tACS boosted the 10-Hz SSVEP significantly. Besides, the aftereffect on SSVEP was mitigated with time and lasted up to 5 min. Our results demonstrate the feasibility of facilitating the flickering driving by external rhythmic stimulation and open a new possibility to alter the brain state in a direction by noninvasive transcranial brain stimulation.
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