形态发生素调控的细胞间接触介导信号传导可驱动脊椎动物体节分割的转变过程
Morphogen-regulated contact-mediated signaling between cells can drive the transitions underlying body segmentation in vertebrates
AI总结：
本文提出一种统一机制，将受体-配体耦合的细胞间相互作用与形态发生素梯度相结合，再现了脊椎动物体节发生中从同步振荡、行波到活动停止及体节样模式出现的完整动力学转变序列。
摘要：
我们提出了一种统一机制，该机制再现了体节发生（即胚胎发育过程中身体分节的过程）期间观察到的动力学转变序列，并且在所有脊椎动物物种中保持不变。这是通过将受体-配体耦合介导的细胞间相互作用与沿前后轴已知存在的形态发生素梯度所引入的全局空间异质性相结合而实现的。我们的模型再现了前体节中胚层（PSM）前部细胞中基因表达的同步振荡，该组织通过在其后部添加新细胞而生长，随后出现行波以及活动的后续停止，最终出现类似体节的模式。该框架将边界组织的模式形成机制（利用形态发生素梯度提供的位置信息）与耦合介导的自组织集体动力学涌现相结合，以解释导致分节的过程。
英文摘要：
We propose a unified mechanism that reproduces the sequence of dynamical transitions observed during somitogenesis, the process of body segmentation during embryonic development, that is invariant across all vertebrate species. This is achieved by combining inter-cellular interactions mediated via receptor-ligand coupling with global spatial heterogeneity introduced through a morphogen gradient known to occur along the anteroposterior axis. Our model reproduces synchronized oscillations in the gene expression in cells at the anterior of the presomitic mesoderm (PSM) as it grows by adding new cells at its posterior, followed by traveling waves and subsequent arrest of activity, with the eventual appearance of somite-like patterns. This framework integrates a boundary-organized pattern formation mechanism, which uses positional information provided by a morphogen gradient, with the coupling-mediated self-organized emergence of collective dynamics, to explain the processes that lead to segmentation.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
