覆盖肌动蛋白套管的膜纳米管的涨落
Fluctuations of a membrane nanotube covered with an actin sleeve
摘要：
许多生物功能依赖于细胞膜的重塑，特别是纳米管，其在体内被动态肌动蛋白网络覆盖。纳米管受到热波动的影响，但这些对细胞功能的影响尚不清楚。在这里，我们使用粘附在脂质体膜上的光学捕获珠粒从脂质体形成纳米管。从这个珠子的功率谱密度，我们研究了在体内测量的膜张力范围内的纳米管波动。我们发现，覆盖在纳米管上的肌动蛋白套筒由于网络的粘弹性而抑制了其高频波动。我们的工作为进一步研究纳米管波动对细胞功能的影响铺平了道路。
英文摘要：
Many biological functions rely on the reshaping of cell membranes, in particular into nanotubes, which are covered in vivo by dynamic actin networks. Nanotubes are subject to thermal fluctuations, but the effect of these on cell functions is unknown. Here, we form nanotubes from liposomes using an optically trapped bead adhering to the liposome membrane. From the power spectral density of this bead, we study the nanotube fluctuations in the range of membrane tensions measured in vivo. We show that an actin sleeve covering the nanotube damps its high frequency fluctuations because of the network viscoelasticity. Our work paves the way for further studies on the effect of nanotube fluctuations in cellular functions.
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